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Lipidome atlas of the adult human brain

Author

Listed:
  • Maria Osetrova

    (Skolkovo Institute of Science and Technology)

  • Anna Tkachev

    (Skolkovo Institute of Science and Technology)

  • Waltraud Mair

    (Skolkovo Institute of Science and Technology)

  • Patricia Guijarro Larraz

    (Skolkovo Institute of Science and Technology)

  • Olga Efimova

    (Skolkovo Institute of Science and Technology)

  • Ilia Kurochkin

    (Skolkovo Institute of Science and Technology)

  • Elena Stekolshchikova

    (Skolkovo Institute of Science and Technology)

  • Nickolay Anikanov

    (Skolkovo Institute of Science and Technology)

  • Juat Chin Foo

    (Yong Loo Lin School of Medicine; National University of Singapore)

  • Amaury Cazenave-Gassiot

    (Yong Loo Lin School of Medicine; National University of Singapore)

  • Aleksandra Mitina

    (Skolkovo Institute of Science and Technology)

  • Polina Ogurtsova

    (Skolkovo Institute of Science and Technology)

  • Song Guo

    (Skolkovo Institute of Science and Technology)

  • Daria M. Potashnikova

    (Lomonosov Moscow State University)

  • Alexander A. Gulin

    (N. N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences)

  • Alexander A. Vasin

    (N. N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences
    Lomonosov Moscow State University)

  • Anastasia Sarycheva

    (Skolkovo Institute of Science and Technology)

  • Gleb Vladimirov

    (Skolkovo Institute of Science and Technology)

  • Maria Fedorova

    (Leipzig University)

  • Yury Kostyukevich

    (Skolkovo Institute of Science and Technology)

  • Evgeny Nikolaev

    (Skolkovo Institute of Science and Technology)

  • Markus R. Wenk

    (Yong Loo Lin School of Medicine; National University of Singapore)

  • Ekaterina E. Khrameeva

    (Skolkovo Institute of Science and Technology)

  • Philipp Khaitovich

    (Skolkovo Institute of Science and Technology)

Abstract

Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain’s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

Suggested Citation

  • Maria Osetrova & Anna Tkachev & Waltraud Mair & Patricia Guijarro Larraz & Olga Efimova & Ilia Kurochkin & Elena Stekolshchikova & Nickolay Anikanov & Juat Chin Foo & Amaury Cazenave-Gassiot & Aleksan, 2024. "Lipidome atlas of the adult human brain," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48734-y
    DOI: 10.1038/s41467-024-48734-y
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    References listed on IDEAS

    as
    1. Stefano Vanni & Hisaaki Hirose & Hélène Barelli & Bruno Antonny & Romain Gautier, 2014. "A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
    2. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
    3. Jun Ding & Jian Ji & Zachary Rabow & Tong Shen & Jacob Folz & Christopher R. Brydges & Sili Fan & Xinchen Lu & Sajjan Mehta & Megan R. Showalter & Ying Zhang & Renee Araiza & Lynette R. Bower & K. C. , 2021. "A metabolome atlas of the aging mouse brain," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Michael J. Hawrylycz & Ed S. Lein & Angela L. Guillozet-Bongaarts & Elaine H. Shen & Lydia Ng & Jeremy A. Miller & Louie N. van de Lagemaat & Kimberly A. Smith & Amanda Ebbert & Zackery L. Riley & Chr, 2012. "An anatomically comprehensive atlas of the adult human brain transcriptome," Nature, Nature, vol. 489(7416), pages 391-399, September.
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