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Insights into the ecology of the infant gut plasmidome

Author

Listed:
  • Wanli He

    (Universitetsparken 15)

  • Jakob Russel

    (Universitetsparken 15)

  • Franziska Klincke

    (Universitetsparken 15)

  • Joseph Nesme

    (Universitetsparken 15)

  • Søren Johannes Sørensen

    (Universitetsparken 15)

Abstract

Plasmids are small DNA molecules that enable bacteria to share beneficial traits, influencing microbial communities. However, their role within the human gut microbiome remains largely unknown. In this study, we investigate the gut microbiomes of 34 mother-child cohorts, employing a plasmid analysis workflow to understand the impact of plasmids on the gut microbiome. We create a plasmid phylogenetic tree, devise a method for assigning plasmid hosts, and examine potential plasmid transfer networks. Our research discovers a wide variety of previously unidentified plasmid sequences, indicating that current databases do not fully represent the gut plasmidome. Interestingly, infants display greater plasmid diversity compared to mothers and other healthy adults. We find that Bacteroidota, a major bacterial phylum, serves as the primary host for gut plasmids and plays a dominant role in gut plasmid transfer events. Additionally, plasmids broaden the genetic capabilities of bacteria, with their influence on bacterial function becoming more apparent as children’s gut microbiomes develop. This study sheds light on the role of plasmids in the infant gut microbiome, making a significant contribution to our understanding of plasmid biology.

Suggested Citation

  • Wanli He & Jakob Russel & Franziska Klincke & Joseph Nesme & Søren Johannes Sørensen, 2024. "Insights into the ecology of the infant gut plasmidome," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51398-3
    DOI: 10.1038/s41467-024-51398-3
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    References listed on IDEAS

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    1. Allison J. Lopatkin & Hannah R. Meredith & Jaydeep K. Srimani & Connor Pfeiffer & Rick Durrett & Lingchong You, 2017. "Persistence and reversal of plasmid-mediated antibiotic resistance," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    2. Joachim Johansen & Damian R. Plichta & Jakob Nybo Nissen & Marie Louise Jespersen & Shiraz A. Shah & Ling Deng & Jakob Stokholm & Hans Bisgaard & Dennis Sandris Nielsen & Søren J. Sørensen & Simon Ras, 2022. "Genome binning of viral entities from bulk metagenomics data," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Mislav Acman & Lucy van Dorp & Joanne M. Santini & Francois Balloux, 2020. "Large-scale network analysis captures biological features of bacterial plasmids," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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