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Stage-dependent role of interhemispheric pathway for motor recovery in primates

Author

Listed:
  • Masahiro Mitsuhashi

    (Kyoto University
    Kyoto University)

  • Reona Yamaguchi

    (Kyoto University)

  • Toshinari Kawasaki

    (Kyoto University
    Kyoto University)

  • Satoko Ueno

    (Kyoto University
    Kyoto University)

  • Yiping Sun

    (Kyoto University)

  • Kaoru Isa

    (Kyoto University)

  • Jun Takahashi

    (Kyoto University)

  • Kenta Kobayashi

    (National Institute for Physiological Sciences
    Graduate University of Advanced Studies (SOKENDAI))

  • Hirotaka Onoe

    (Kyoto University)

  • Ryosuke Takahashi

    (Kyoto University)

  • Tadashi Isa

    (Kyoto University
    Kyoto University
    Kyoto University)

Abstract

Whether and how the non-lesional sensorimotor cortex is activated and contributes to post-injury motor recovery is controversial. Here, we investigated the role of interhemispheric pathway from the contralesional to ipsilesional premotor cortex in activating the ipsilesional sensorimotor cortex and promoting recovery after lesioning the lateral corticospinal tract at the cervical cord, by unidirectional chemogenetic blockade in macaques. The blockade impaired dexterous hand movements during the early recovery stage. Electrocorticographical recording showed that the low frequency band activity of the ipsilesional premotor cortex around movement onset was decreased by the blockade during the early recovery stage, while it was increased by blockade during the intact state and late recovery stage. These results demonstrate that action of the interhemispheric pathway changed from inhibition to facilitation, to involve the ipsilesional sensorimotor cortex in hand movements during the early recovery stage. The present study offers insights into the stage-dependent role of the interhemispheric pathway and a therapeutic target in the early recovery stage after lesioning of the corticospinal tract.

Suggested Citation

  • Masahiro Mitsuhashi & Reona Yamaguchi & Toshinari Kawasaki & Satoko Ueno & Yiping Sun & Kaoru Isa & Jun Takahashi & Kenta Kobayashi & Hirotaka Onoe & Ryosuke Takahashi & Tadashi Isa, 2024. "Stage-dependent role of interhemispheric pathway for motor recovery in primates," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51070-w
    DOI: 10.1038/s41467-024-51070-w
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    References listed on IDEAS

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    1. Masaharu Kinoshita & Ryosuke Matsui & Shigeki Kato & Taku Hasegawa & Hironori Kasahara & Kaoru Isa & Akiya Watakabe & Tetsuo Yamamori & Yukio Nishimura & Bror Alstermark & Dai Watanabe & Kazuto Kobaya, 2012. "Genetic dissection of the circuit for hand dexterity in primates," Nature, Nature, vol. 487(7406), pages 235-238, July.
    2. Yuji Nagai & Erika Kikuchi & Walter Lerchner & Ken-ichi Inoue & Bin Ji & Mark A. G. Eldridge & Hiroyuki Kaneko & Yasuyuki Kimura & Arata Oh-Nishi & Yukiko Hori & Yoko Kato & Toshiyuki Hirabayashi & At, 2016. "PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    3. Roger A. Barker & Magdalena Götz & Malin Parmar, 2018. "New approaches for brain repair—from rescue to reprogramming," Nature, Nature, vol. 557(7705), pages 329-334, May.
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