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Genetic dissection of the circuit for hand dexterity in primates

Author

Listed:
  • Masaharu Kinoshita

    (National Institute for Physiological Sciences)

  • Ryosuke Matsui

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

  • Shigeki Kato

    (Institute of Biomedical Sciences, Fukushima Medical University School of Medicine)

  • Taku Hasegawa

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

  • Hironori Kasahara

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

  • Kaoru Isa

    (National Institute for Physiological Sciences)

  • Akiya Watakabe

    (National Institute for Basic Biology
    The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan)

  • Tetsuo Yamamori

    (National Institute for Basic Biology
    The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan)

  • Yukio Nishimura

    (National Institute for Physiological Sciences
    The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan
    Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Chiyoda, Tokyo 102-0076, Japan)

  • Bror Alstermark

    (section of Physiology, Umeå University, S-901 87 Umeå, Sweden)

  • Dai Watanabe

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)

  • Kazuto Kobayashi

    (Institute of Biomedical Sciences, Fukushima Medical University School of Medicine)

  • Tadashi Isa

    (National Institute for Physiological Sciences
    The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan)

Abstract

A new double-infection technique with viral vectors is used to interrupt transmission through the propriospinal neurons (PNs) in macaque monkeys, and this is found to impair reach and grasp movements, revealing a critical role for the PN-mediated pathway in the control of hand dexterity.

Suggested Citation

  • Masaharu Kinoshita & Ryosuke Matsui & Shigeki Kato & Taku Hasegawa & Hironori Kasahara & Kaoru Isa & Akiya Watakabe & Tetsuo Yamamori & Yukio Nishimura & Bror Alstermark & Dai Watanabe & Kazuto Kobaya, 2012. "Genetic dissection of the circuit for hand dexterity in primates," Nature, Nature, vol. 487(7406), pages 235-238, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7406:d:10.1038_nature11206
    DOI: 10.1038/nature11206
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    Cited by:

    1. Masahiro Mitsuhashi & Reona Yamaguchi & Toshinari Kawasaki & Satoko Ueno & Yiping Sun & Kaoru Isa & Jun Takahashi & Kenta Kobayashi & Hirotaka Onoe & Ryosuke Takahashi & Tadashi Isa, 2024. "Stage-dependent role of interhemispheric pathway for motor recovery in primates," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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