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New approaches for brain repair—from rescue to reprogramming

Author

Listed:
  • Roger A. Barker

    (University of Cambridge)

  • Magdalena Götz

    (Ludwig-Maximilians University
    Center for Stroke and Dementia)

  • Malin Parmar

    (Lund University)

Abstract

The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

Suggested Citation

  • Roger A. Barker & Magdalena Götz & Malin Parmar, 2018. "New approaches for brain repair—from rescue to reprogramming," Nature, Nature, vol. 557(7705), pages 329-334, May.
    • Handle: RePEc:nat:nature:v:557:y:2018:i:7705:d:10.1038_s41586-018-0087-1
    DOI: 10.1038/s41586-018-0087-1
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    Cited by:

    1. Chikako Nakajima & Masato Sawada & Erika Umeda & Yuma Takagi & Norihiko Nakashima & Kazuya Kuboyama & Naoko Kaneko & Satoaki Yamamoto & Haruno Nakamura & Naoki Shimada & Koichiro Nakamura & Kumiko Mat, 2024. "Identification of the growth cone as a probe and driver of neuronal migration in the injured brain," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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