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Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity

Author

Listed:
  • Shengjie Wei

    (Nankai University
    Tsinghua University)

  • Wenjie Ma

    (The Chinese Academy of Sciences (CAS))

  • Minmin Sun

    (Yangzhou University)

  • Pan Xiang

    (Chinese Academy of Sciences)

  • Ziqi Tian

    (Chinese Academy of Sciences)

  • Lanqun Mao

    (Beijing Normal University)

  • Lizeng Gao

    (Chinese Academy of Sciences)

  • Yadong Li

    (Tsinghua University)

Abstract

Constructing atom-pair engineering and improving the activity of metal single-atom nanozyme (SAzyme) is significant but challenging. Herein, we design the atom-pair engineering of Zn-SA/CNCl SAzyme by simultaneously constructing Zn-N4 sites as catalytic sites and Zn-N4Cl1 sites as catalytic regulator. The Zn-N4Cl1 catalytic regulators effectively boost the peroxidase-like activities of Zn-N4 catalytic sites, resulting in a 346-fold, 1496-fold, and 133-fold increase in the maximal reaction velocity, the catalytic constant and the catalytic efficiency, compared to Zn-SA/CN SAzyme without the Zn-N4Cl1 catalytic regulator. The Zn-SA/CNCl SAzyme with excellent peroxidase-like activity effectively inhibits tumor cell growth in vitro and in vivo. The density functional theory (DFT) calculations reveal that the Zn-N4Cl1 catalytic regulators facilitate the adsorption of *H2O2 and re-exposure of Zn-N4 catalytic sites, and thus improve the reaction rate. This work provides a rational and effective strategy for improving the peroxidase-like activity of metal SAzyme by atom-pair engineering.

Suggested Citation

  • Shengjie Wei & Wenjie Ma & Minmin Sun & Pan Xiang & Ziqi Tian & Lanqun Mao & Lizeng Gao & Yadong Li, 2024. "Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51022-4
    DOI: 10.1038/s41467-024-51022-4
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    References listed on IDEAS

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    1. Ali Han & Xiaofeng Zhou & Xijun Wang & Sheng Liu & Qihua Xiong & Qinghua Zhang & Lin Gu & Zechao Zhuang & Wenjing Zhang & Fanxing Li & Dingsheng Wang & Lain-Jong Li & Yadong Li, 2021. "One-step synthesis of single-site vanadium substitution in 1T-WS2 monolayers for enhanced hydrogen evolution catalysis," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Shengjie Wei & Yibing Sun & Yun-Ze Qiu & Ang Li & Ching-Yu Chiang & Hai Xiao & Jieshu Qian & Yadong Li, 2023. "Self-carbon-thermal-reduction strategy for boosting the Fenton-like activity of single Fe-N4 sites by carbon-defect engineering," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Yiwei Liu & Xi Wu & Zhi Li & Jian Zhang & Shu-Xia Liu & Shoujie Liu & Lin Gu & Li Rong Zheng & Jia Li & Dingsheng Wang & Yadong Li, 2021. "Fabricating polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    4. Shuizhong Wang & Kaili Zhang & Helong Li & Ling-Ping Xiao & Guoyong Song, 2021. "Selective hydrogenolysis of catechyl lignin into propenylcatechol over an atomically dispersed ruthenium catalyst," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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