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Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

Author

Listed:
  • Rebeka Butkovič

    (University of Bristol)

  • Alexander P. Walker

    (University of Bristol)

  • Michael D. Healy

    (The University of Queensland)

  • Kerrie E. McNally

    (University of Bristol
    MRC Laboratory of Molecular Biology)

  • Meihan Liu

    (The University of Queensland)

  • Tineke Veenendaal

    (Utrecht University)

  • Kohji Kato

    (University of Bristol)

  • Nalan Liv

    (Utrecht University)

  • Judith Klumperman

    (Utrecht University)

  • Brett M. Collins

    (The University of Queensland)

  • Peter J. Cullen

    (University of Bristol)

Abstract

Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the structure of this complex has recently been described, how cargo proteins are selected for Commander-mediated recycling remains unclear. Here we identify the mechanism through which the unstructured carboxy-terminal tail of the cargo adaptor sorting nexin-17 (SNX17) directly binds to the Retriever sub-complex of Commander. SNX17 adopts an autoinhibited conformation where its carboxy-terminal tail occupies the cargo binding groove. Competitive cargo binding overcomes this autoinhibition, promoting SNX17 endosomal residency and the release of the tail for Retriever association. Furthermore, our study establishes the central importance of SNX17-Retriever association in the handover of integrin and lipoprotein receptor cargoes into pre-existing endosomal retrieval sub-domains. In describing the principal mechanism of cargo entry into the Commander recycling pathway we provide key insight into the function and regulation of this evolutionary conserved sorting pathway.

Suggested Citation

  • Rebeka Butkovič & Alexander P. Walker & Michael D. Healy & Kerrie E. McNally & Meihan Liu & Tineke Veenendaal & Kohji Kato & Nalan Liv & Judith Klumperman & Brett M. Collins & Peter J. Cullen, 2024. "Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50971-0
    DOI: 10.1038/s41467-024-50971-0
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