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The critical dynamics of hippocampal seizures

Author

Listed:
  • Gregory Lepeu

    (University of Bern)

  • Ellen Maren

    (University of Bern)

  • Kristina Slabeva

    (University of Bern)

  • Cecilia Friedrichs-Maeder

    (University of Bern)

  • Markus Fuchs

    (University of Bern)

  • Werner J. Z’Graggen

    (University of Bern)

  • Claudio Pollo

    (University of Bern)

  • Kaspar A. Schindler

    (University of Bern)

  • Antoine Adamantidis

    (University of Bern)

  • Timothée Proix

    (University of Geneva)

  • Maxime O. Baud

    (University of Bern)

Abstract

Epilepsy is defined by the abrupt emergence of harmful seizures, but the nature of these regime shifts remains enigmatic. From the perspective of dynamical systems theory, such critical transitions occur upon inconspicuous perturbations in highly interconnected systems and can be modeled as mathematical bifurcations between alternative regimes. The predictability of critical transitions represents a major challenge, but the theory predicts the appearance of subtle dynamical signatures on the verge of instability. Whether such dynamical signatures can be measured before impending seizures remains uncertain. Here, we verified that predictions on bifurcations applied to the onset of hippocampal seizures, providing concordant results from in silico modeling, optogenetics experiments in male mice and intracranial EEG recordings in human patients with epilepsy. Leveraging pharmacological control over neural excitability, we showed that the boundary between physiological excitability and seizures can be inferred from dynamical signatures passively recorded or actively probed in hippocampal circuits. Of importance for the design of future neurotechnologies, active probing surpassed passive recording to decode underlying levels of neural excitability, notably when assessed from a network of propagating neural responses. Our findings provide a promising approach for predicting and preventing seizures, based on a sound understanding of their dynamics.

Suggested Citation

  • Gregory Lepeu & Ellen Maren & Kristina Slabeva & Cecilia Friedrichs-Maeder & Markus Fuchs & Werner J. Z’Graggen & Claudio Pollo & Kaspar A. Schindler & Antoine Adamantidis & Timothée Proix & Maxime O., 2024. "The critical dynamics of hippocampal seizures," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50504-9
    DOI: 10.1038/s41467-024-50504-9
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    References listed on IDEAS

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