IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-50268-2.html
   My bibliography  Save this article

Population structure and antibiotic resistance of swine extraintestinal pathogenic Escherichia coli from China

Author

Listed:
  • Xudong Li

    (Huazhong Agricultural University
    Huazhong Agricultural University)

  • Huifeng Hu

    (Huazhong Agricultural University
    Huazhong Agricultural University
    University of Vienna)

  • Yongwei Zhu

    (Huazhong Agricultural University
    Huazhong Agricultural University
    Frontiers Science Center for Animal Breeding and Sustainable Production)

  • Taiquan Wang

    (Huazhong Agricultural University
    Huazhong Agricultural University)

  • Youlan Lu

    (Huazhong Agricultural University
    Huazhong Agricultural University)

  • Xiangru Wang

    (Huazhong Agricultural University
    Huazhong Agricultural University
    Frontiers Science Center for Animal Breeding and Sustainable Production)

  • Zhong Peng

    (Huazhong Agricultural University
    Huazhong Agricultural University
    Frontiers Science Center for Animal Breeding and Sustainable Production)

  • Ming Sun

    (Huazhong Agricultural University)

  • Huanchun Chen

    (Huazhong Agricultural University
    Huazhong Agricultural University
    Frontiers Science Center for Animal Breeding and Sustainable Production)

  • Jinshui Zheng

    (Huazhong Agricultural University
    Huazhong Agricultural University)

  • Chen Tan

    (Huazhong Agricultural University
    Huazhong Agricultural University
    Frontiers Science Center for Animal Breeding and Sustainable Production)

Abstract

Extraintestinal Pathogenic Escherichia coli (ExPEC) pose a significant threat to human and animal health. However, the diversity and antibiotic resistance of animal ExPEC, and their connection to human infections, remain largely unexplored. The study performs large-scale genome sequencing and antibiotic resistance testing of 499 swine-derived ExPEC isolates from China. Results show swine ExPEC are phylogenetically diverse, with over 80% belonging to phylogroups B1 and A. Importantly, 15 swine ExPEC isolates exhibit genetic relatedness to human-origin E. coli strains. Additionally, 49 strains harbor toxins typical of enteric E. coli pathotypes, implying hybrid pathotypes. Notably, 97% of the total strains are multidrug resistant, including resistance to critical human drugs like third- and fourth-generation cephalosporins. Correspondingly, genomic analysis unveils prevalent antibiotic resistance genes (ARGs), often associated with co-transfer mechanisms. Furthermore, analysis of 20 complete genomes illuminates the transmission pathways of ARGs within swine ExPEC and to human pathogens. For example, the transmission of plasmids co-harboring fosA3, blaCTX-M-14, and mcr-1 genes between swine ExPEC and human-origin Salmonella enterica is observed. These findings underscore the importance of monitoring and controlling ExPEC infections in animals, as they can serve as a reservoir of ARGs with the potential to affect human health or even be the origin of pathogens infecting humans.

Suggested Citation

  • Xudong Li & Huifeng Hu & Yongwei Zhu & Taiquan Wang & Youlan Lu & Xiangru Wang & Zhong Peng & Ming Sun & Huanchun Chen & Jinshui Zheng & Chen Tan, 2024. "Population structure and antibiotic resistance of swine extraintestinal pathogenic Escherichia coli from China," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50268-2
    DOI: 10.1038/s41467-024-50268-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-50268-2
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-50268-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ruobing Wang & Lucy Dorp & Liam P. Shaw & Phelim Bradley & Qi Wang & Xiaojuan Wang & Longyang Jin & Qing Zhang & Yuqing Liu & Adrien Rieux & Thamarai Dorai-Schneiders & Lucy Anne Weinert & Zamin Iqbal, 2018. "The global distribution and spread of the mobilized colistin resistance gene mcr-1," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    2. Zhong Peng & Zizhe Hu & Zugang Li & Xiaoxue Zhang & Chaoying Jia & Tianzhi Li & Menghong Dai & Chen Tan & Zhuofei Xu & Bin Wu & Huanchun Chen & Xiangru Wang, 2022. "Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Ewa Bok & Aleksandra Kożańska & Justyna Mazurek-Popczyk & Magdalena Wojciech & Katarzyna Baldy-Chudzik, 2020. "Extended Phylogeny and Extraintestinal Virulence Potential of Commensal Escherichia coli from Piglets and Sows," IJERPH, MDPI, vol. 17(1), pages 1-17, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Clare I. R. Chandler, 2019. "Current accounts of antimicrobial resistance: stabilisation, individualisation and antibiotics as infrastructure," Palgrave Communications, Palgrave Macmillan, vol. 5(1), pages 1-13, December.
    2. Swapnil Prakash Doijad & Nicolas Gisch & Renate Frantz & Bajarang Vasant Kumbhar & Jane Falgenhauer & Can Imirzalioglu & Linda Falgenhauer & Alexander Mischnik & Jan Rupp & Michael Behnke & Michael Bu, 2023. "Resolving colistin resistance and heteroresistance in Enterobacter species," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. E. A. R. Portal & K. Sands & C. Farley & I. Boostrom & E. Jones & M. Barrell & M. J. Carvalho & R. Milton & K. Iregbu & F. Modibbo & S. Uwaezuoke & C. Akpulu & L. Audu & C. Edwin & A. H. Yusuf & A. Ad, 2024. "Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Yunyan Zhou & Jingquan Li & Fei Huang & Huashui Ai & Jun Gao & Congying Chen & Lusheng Huang, 2023. "Characterization of the pig lower respiratory tract antibiotic resistome," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Chan, Olivia S.K. & Lam, Wendy & Zhao, Shilin & Tun, Hein & Liu, Ping & Wu, Peng, 2024. "Why prescribe antibiotics? A systematic review of knowledge, tension, and motivation among clinicians in low-, middle- and high-income countries," Social Science & Medicine, Elsevier, vol. 345(C).
    6. Mislav Acman & Ruobing Wang & Lucy Dorp & Liam P. Shaw & Qi Wang & Nina Luhmann & Yuyao Yin & Shijun Sun & Hongbin Chen & Hui Wang & Francois Balloux, 2022. "Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    7. Georges P. Schmartz & Jacqueline Rehner & Madline P. Gund & Verena Keller & Leidy-Alejandra G. Molano & Stefan Rupf & Matthias Hannig & Tim Berger & Elias Flockerzi & Berthold Seitz & Sara Fleser & Sa, 2024. "Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50268-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.