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Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China

Author

Listed:
  • Zhong Peng

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Zizhe Hu

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Zugang Li

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Xiaoxue Zhang

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Chaoying Jia

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Tianzhi Li

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Menghong Dai

    (Huazhong Agricultural University)

  • Chen Tan

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Zhuofei Xu

    (Shanghai MasScience Biotechnology Institute)

  • Bin Wu

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Huanchun Chen

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

  • Xiangru Wang

    (Huazhong Agricultural University
    Cooperative Innovation Centre for Sustainable Pig Production)

Abstract

The expanding use of antimicrobials in livestock is an important contributor to the worldwide rapid increase in antimicrobial resistance (AMR). However, large-scale studies on AMR in livestock remain scarce. Here, we report findings from surveillance of E. coli AMR in pig farms in China in 2018–2019. We isolated E. coli in 1,871 samples from pigs and their breeding environments, and found AMR in E. coli in all provinces in mainland China. We detected multidrug-resistance in 91% isolates and found resistance to last-resort drugs including colistin, carbapenems and tigecycline. We also identified a heterogeneous group of O-serogroups and sequence types among the multidrug-resistant isolates. These isolates harbored multiple resistance genes, virulence factor-encoding genes, and putative plasmids. Our data will help to understand the current AMR profiles of pigs and provide a reference for AMR control policy formulation for livestock in China.

Suggested Citation

  • Zhong Peng & Zizhe Hu & Zugang Li & Xiaoxue Zhang & Chaoying Jia & Tianzhi Li & Menghong Dai & Chen Tan & Zhuofei Xu & Bin Wu & Huanchun Chen & Xiangru Wang, 2022. "Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28750-6
    DOI: 10.1038/s41467-022-28750-6
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    Cited by:

    1. Chan, Olivia S.K. & Lam, Wendy & Zhao, Shilin & Tun, Hein & Liu, Ping & Wu, Peng, 2024. "Why prescribe antibiotics? A systematic review of knowledge, tension, and motivation among clinicians in low-, middle- and high-income countries," Social Science & Medicine, Elsevier, vol. 345(C).

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