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The global distribution and spread of the mobilized colistin resistance gene mcr-1

Author

Listed:
  • Ruobing Wang

    (Peking University People’s Hospital)

  • Lucy Dorp

    (University College London)

  • Liam P. Shaw

    (University College London)

  • Phelim Bradley

    (University of Oxford)

  • Qi Wang

    (Peking University People’s Hospital)

  • Xiaojuan Wang

    (Peking University People’s Hospital)

  • Longyang Jin

    (Peking University People’s Hospital)

  • Qing Zhang

    (Shandong Province)

  • Yuqing Liu

    (Shandong Province)

  • Adrien Rieux

    (UMR PVBMT, CIRAD)

  • Thamarai Dorai-Schneiders

    (49 Little France Crescent)

  • Lucy Anne Weinert

    (Department of Veterinary Medicine)

  • Zamin Iqbal

    (University of Oxford
    Wellcome Genome Campus)

  • Xavier Didelot

    (Imperial College London)

  • Hui Wang

    (Peking University People’s Hospital)

  • Francois Balloux

    (University College London)

Abstract

Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

Suggested Citation

  • Ruobing Wang & Lucy Dorp & Liam P. Shaw & Phelim Bradley & Qi Wang & Xiaojuan Wang & Longyang Jin & Qing Zhang & Yuqing Liu & Adrien Rieux & Thamarai Dorai-Schneiders & Lucy Anne Weinert & Zamin Iqbal, 2018. "The global distribution and spread of the mobilized colistin resistance gene mcr-1," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03205-z
    DOI: 10.1038/s41467-018-03205-z
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    Cited by:

    1. Mislav Acman & Ruobing Wang & Lucy Dorp & Liam P. Shaw & Qi Wang & Nina Luhmann & Yuyao Yin & Shijun Sun & Hongbin Chen & Hui Wang & Francois Balloux, 2022. "Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Yunyan Zhou & Jingquan Li & Fei Huang & Huashui Ai & Jun Gao & Congying Chen & Lusheng Huang, 2023. "Characterization of the pig lower respiratory tract antibiotic resistome," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. E. A. R. Portal & K. Sands & C. Farley & I. Boostrom & E. Jones & M. Barrell & M. J. Carvalho & R. Milton & K. Iregbu & F. Modibbo & S. Uwaezuoke & C. Akpulu & L. Audu & C. Edwin & A. H. Yusuf & A. Ad, 2024. "Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Clare I. R. Chandler, 2019. "Current accounts of antimicrobial resistance: stabilisation, individualisation and antibiotics as infrastructure," Palgrave Communications, Palgrave Macmillan, vol. 5(1), pages 1-13, December.
    5. Swapnil Prakash Doijad & Nicolas Gisch & Renate Frantz & Bajarang Vasant Kumbhar & Jane Falgenhauer & Can Imirzalioglu & Linda Falgenhauer & Alexander Mischnik & Jan Rupp & Michael Behnke & Michael Bu, 2023. "Resolving colistin resistance and heteroresistance in Enterobacter species," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Georges P. Schmartz & Jacqueline Rehner & Madline P. Gund & Verena Keller & Leidy-Alejandra G. Molano & Stefan Rupf & Matthias Hannig & Tim Berger & Elias Flockerzi & Berthold Seitz & Sara Fleser & Sa, 2024. "Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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