IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45673-6.html
   My bibliography  Save this article

Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria

Author

Listed:
  • E. A. R. Portal

    (Cardiff University
    University of Oxford)

  • K. Sands

    (Cardiff University
    University of Oxford)

  • C. Farley

    (Cardiff University)

  • I. Boostrom

    (Cardiff University)

  • E. Jones

    (Cardiff University)

  • M. Barrell

    (Cardiff University)

  • M. J. Carvalho

    (Cardiff University
    University of Aveiro)

  • R. Milton

    (Cardiff University
    Cardiff University)

  • K. Iregbu

    (National Hospital Abuja)

  • F. Modibbo

    (Murtala Muhammad Specialist Hospital)

  • S. Uwaezuoke

    (Federal Medical Centre –Jabi)

  • C. Akpulu

    (University of Oxford
    National Hospital Abuja
    University of Oxford)

  • L. Audu

    (National Hospital Abuja)

  • C. Edwin

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • A. H. Yusuf

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • A. Adeleye

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • A. S. Mukkadas

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • D. Maduekwe

    (Wuse General Hospital Abuja)

  • S. Gambo

    (Murtala Muhammed Specialist Hospital)

  • J. Sani

    (Department of Paediatrics Abdullahi Wase Teaching Hospital)

  • T. R. Walsh

    (Cardiff University
    University of Oxford)

  • O. B. Spiller

    (Cardiff University)

Abstract

A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing prevalence across South-East Asia. Here we survey the presence of mcr genes in 4907 rectal swabs from mothers and neonates from three hospital sites across Nigeria; a country with limited availability or history of colistin use clinically. Forty mother and seven neonatal swabs carried mcr genes in a range of bacterial species: 46 Enterobacter spp. and single isolates of; Shigella, E. coli and Klebsiella quasipneumoniae. Ninety percent of the genes were mcr-10 (n = 45) we also found mcr-1 (n = 3) and mcr-9 (n = 1). While the prevalence during this collection (2015-2016) was low, the widespread diversity of mcr-gene type and range of bacterial species in this sentinel population sampling is concerning. It suggests that agricultural colistin use was likely encouraging sustainment of mcr-positive isolates in the community and implementation of medical colistin use will rapidly select and expand resistant isolates.

Suggested Citation

  • E. A. R. Portal & K. Sands & C. Farley & I. Boostrom & E. Jones & M. Barrell & M. J. Carvalho & R. Milton & K. Iregbu & F. Modibbo & S. Uwaezuoke & C. Akpulu & L. Audu & C. Edwin & A. H. Yusuf & A. Ad, 2024. "Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45673-6
    DOI: 10.1038/s41467-024-45673-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45673-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45673-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ruobing Wang & Lucy Dorp & Liam P. Shaw & Phelim Bradley & Qi Wang & Xiaojuan Wang & Longyang Jin & Qing Zhang & Yuqing Liu & Adrien Rieux & Thamarai Dorai-Schneiders & Lucy Anne Weinert & Zamin Iqbal, 2018. "The global distribution and spread of the mobilized colistin resistance gene mcr-1," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    2. Swapnil Prakash Doijad & Nicolas Gisch & Renate Frantz & Bajarang Vasant Kumbhar & Jane Falgenhauer & Can Imirzalioglu & Linda Falgenhauer & Alexander Mischnik & Jan Rupp & Michael Behnke & Michael Bu, 2023. "Resolving colistin resistance and heteroresistance in Enterobacter species," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Clare I. R. Chandler, 2019. "Current accounts of antimicrobial resistance: stabilisation, individualisation and antibiotics as infrastructure," Palgrave Communications, Palgrave Macmillan, vol. 5(1), pages 1-13, December.
    2. Swapnil Prakash Doijad & Nicolas Gisch & Renate Frantz & Bajarang Vasant Kumbhar & Jane Falgenhauer & Can Imirzalioglu & Linda Falgenhauer & Alexander Mischnik & Jan Rupp & Michael Behnke & Michael Bu, 2023. "Resolving colistin resistance and heteroresistance in Enterobacter species," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yunyan Zhou & Jingquan Li & Fei Huang & Huashui Ai & Jun Gao & Congying Chen & Lusheng Huang, 2023. "Characterization of the pig lower respiratory tract antibiotic resistome," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Mislav Acman & Ruobing Wang & Lucy Dorp & Liam P. Shaw & Qi Wang & Nina Luhmann & Yuyao Yin & Shijun Sun & Hongbin Chen & Hui Wang & Francois Balloux, 2022. "Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45673-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.