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Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria

Author

Listed:
  • E. A. R. Portal

    (Cardiff University
    University of Oxford)

  • K. Sands

    (Cardiff University
    University of Oxford)

  • C. Farley

    (Cardiff University)

  • I. Boostrom

    (Cardiff University)

  • E. Jones

    (Cardiff University)

  • M. Barrell

    (Cardiff University)

  • M. J. Carvalho

    (Cardiff University
    University of Aveiro)

  • R. Milton

    (Cardiff University
    Cardiff University)

  • K. Iregbu

    (National Hospital Abuja)

  • F. Modibbo

    (Murtala Muhammad Specialist Hospital)

  • S. Uwaezuoke

    (Federal Medical Centre –Jabi)

  • C. Akpulu

    (University of Oxford
    National Hospital Abuja
    University of Oxford)

  • L. Audu

    (National Hospital Abuja)

  • C. Edwin

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • A. H. Yusuf

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • A. Adeleye

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • A. S. Mukkadas

    (Department of Medical Microbiology Aminu Kano Teaching Hospital)

  • D. Maduekwe

    (Wuse General Hospital Abuja)

  • S. Gambo

    (Murtala Muhammed Specialist Hospital)

  • J. Sani

    (Department of Paediatrics Abdullahi Wase Teaching Hospital)

  • T. R. Walsh

    (Cardiff University
    University of Oxford)

  • O. B. Spiller

    (Cardiff University)

Abstract

A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing prevalence across South-East Asia. Here we survey the presence of mcr genes in 4907 rectal swabs from mothers and neonates from three hospital sites across Nigeria; a country with limited availability or history of colistin use clinically. Forty mother and seven neonatal swabs carried mcr genes in a range of bacterial species: 46 Enterobacter spp. and single isolates of; Shigella, E. coli and Klebsiella quasipneumoniae. Ninety percent of the genes were mcr-10 (n = 45) we also found mcr-1 (n = 3) and mcr-9 (n = 1). While the prevalence during this collection (2015-2016) was low, the widespread diversity of mcr-gene type and range of bacterial species in this sentinel population sampling is concerning. It suggests that agricultural colistin use was likely encouraging sustainment of mcr-positive isolates in the community and implementation of medical colistin use will rapidly select and expand resistant isolates.

Suggested Citation

  • E. A. R. Portal & K. Sands & C. Farley & I. Boostrom & E. Jones & M. Barrell & M. J. Carvalho & R. Milton & K. Iregbu & F. Modibbo & S. Uwaezuoke & C. Akpulu & L. Audu & C. Edwin & A. H. Yusuf & A. Ad, 2024. "Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45673-6
    DOI: 10.1038/s41467-024-45673-6
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    References listed on IDEAS

    as
    1. Ruobing Wang & Lucy Dorp & Liam P. Shaw & Phelim Bradley & Qi Wang & Xiaojuan Wang & Longyang Jin & Qing Zhang & Yuqing Liu & Adrien Rieux & Thamarai Dorai-Schneiders & Lucy Anne Weinert & Zamin Iqbal, 2018. "The global distribution and spread of the mobilized colistin resistance gene mcr-1," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    2. Swapnil Prakash Doijad & Nicolas Gisch & Renate Frantz & Bajarang Vasant Kumbhar & Jane Falgenhauer & Can Imirzalioglu & Linda Falgenhauer & Alexander Mischnik & Jan Rupp & Michael Behnke & Michael Bu, 2023. "Resolving colistin resistance and heteroresistance in Enterobacter species," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

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