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The mouse multi-organ proteome from infancy to adulthood

Author

Listed:
  • Qingwen Wang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Xinwen Ding

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Zhixiao Xu

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Boqian Wang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Aiting Wang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Liping Wang

    (Shanghai Jiao Tong University)

  • Yi Ding

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Sunfengda Song

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Youming Chen

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Shuang Zhang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Lai Jiang

    (Shanghai Jiao Tong University)

  • Xianting Ding

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

Abstract

The early-life organ development and maturation shape the fundamental blueprint for later-life phenotype. However, a multi-organ proteome atlas from infancy to adulthood is currently not available. Herein, we present a comprehensive proteomic analysis of ten mouse organs (brain, heart, lung, liver, kidney, spleen, stomach, intestine, muscle and skin) at three crucial developmental stages (1-, 4- and 8-weeks after birth) acquired using data-independent acquisition mass spectrometry. We detect and quantify 11,533 protein groups across the ten organs and obtain 115 age-related differentially expressed protein groups that are co-expressed in all organs from infancy to adulthood. We find that spliceosome proteins prevalently play crucial regulatory roles in the early-life development of multiple organs, and detect organ-specific expression patterns and sexual dimorphism. This multi-organ proteome atlas provides a fundamental resource for understanding the molecular mechanisms underlying early-life organ development and maturation.

Suggested Citation

  • Qingwen Wang & Xinwen Ding & Zhixiao Xu & Boqian Wang & Aiting Wang & Liping Wang & Yi Ding & Sunfengda Song & Youming Chen & Shuang Zhang & Lai Jiang & Xianting Ding, 2024. "The mouse multi-organ proteome from infancy to adulthood," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50183-6
    DOI: 10.1038/s41467-024-50183-6
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    References listed on IDEAS

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