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Neurovascular coupling during hypercapnia in cerebral blood flow regulation

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  • Grant R. Gordon

    (University of Calgary)

Abstract

Neuronal activity consumes cellular energy and generates carbon dioxide (CO2). To counter this metabolic challenge, synaptic signalling communicates with nearby microvasculature to increase local blood flow. Is this process solely based on feedforward synaptic signalling, or is the generated CO2 also involved? This question was addressed in mice in a new Nature Communications publication by Tournissac and colleagues where they showed that neurovascular coupling is not affected by exogenous CO2 or its associated acidification.

Suggested Citation

  • Grant R. Gordon, 2024. "Neurovascular coupling during hypercapnia in cerebral blood flow regulation," Nature Communications, Nature, vol. 15(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50165-8
    DOI: 10.1038/s41467-024-50165-8
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    References listed on IDEAS

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    1. Davide Boido & Ravi L. Rungta & Bruno-Félix Osmanski & Morgane Roche & Tomokazu Tsurugizawa & Denis Bihan & Luisa Ciobanu & Serge Charpak, 2019. "Mesoscopic and microscopic imaging of sensory responses in the same animal," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    2. Marine Tournissac & Emmanuelle Chaigneau & Sonia Pfister & Ali-Kemal Aydin & Yannick Goulam Houssen & Philip O’Herron & Jessica Filosa & Mayeul Collot & Anne Joutel & Serge Charpak, 2024. "Neurovascular coupling and CO2 interrogate distinct vascular regulations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Patrick S. Hosford & Jack A. Wells & Shereen Nizari & Isabel N. Christie & Shefeeq M. Theparambil & Pablo A. Castro & Anna Hadjihambi & L. Felipe Barros & Iván Ruminot & Mark F. Lythgoe & Alexander V., 2022. "CO2 signaling mediates neurovascular coupling in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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