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Robust trigger wave speed in Xenopus cytoplasmic extracts

Author

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  • Jo-Hsi Huang

    (Stanford University School of Medicine)

  • Yuping Chen

    (Stanford University School of Medicine
    Chinese Academy of Sciences)

  • William Y. C. Huang

    (Stanford University School of Medicine)

  • Saman Tabatabaee

    (Stanford University School of Medicine)

  • James E. Ferrell

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Self-regenerating trigger waves can spread rapidly through the crowded cytoplasm without diminishing in amplitude or speed, providing consistent, reliable, long-range communication. The macromolecular concentration of the cytoplasm varies in response to physiological and environmental fluctuations, raising the question of how or if trigger waves can robustly operate in the face of such fluctuations. Using Xenopus extracts, we find that mitotic and apoptotic trigger wave speeds are remarkably invariant. We derive a model that accounts for this robustness and for the eventual slowing at extremely high and low cytoplasmic concentrations. The model implies that the positive and negative effects of cytoplasmic concentration (increased reactant concentration vs. increased viscosity) are nearly precisely balanced. Accordingly, artificially maintaining a constant cytoplasmic viscosity during dilution abrogates this robustness. The robustness in trigger wave speeds may contribute to the reliability of the extremely rapid embryonic cell cycle.

Suggested Citation

  • Jo-Hsi Huang & Yuping Chen & William Y. C. Huang & Saman Tabatabaee & James E. Ferrell, 2024. "Robust trigger wave speed in Xenopus cytoplasmic extracts," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50119-0
    DOI: 10.1038/s41467-024-50119-0
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    References listed on IDEAS

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    1. Kimberly L. Cooper & Seungeun Oh & Yongjin Sung & Ramachandra R. Dasari & Marc W. Kirschner & Clifford J. Tabin, 2013. "Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions," Nature, Nature, vol. 495(7441), pages 375-378, March.
    2. Yuping Chen & Jo-Hsi Huang & Connie Phong & James E. Ferrell, 2024. "Viscosity-dependent control of protein synthesis and degradation," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Alessandro De Simone & Maya N. Evanitsky & Luke Hayden & Ben D. Cox & Julia Wang & Valerie A. Tornini & Jianhong Ou & Anna Chao & Kenneth D. Poss & Stefano Di Talia, 2021. "Control of osteoblast regeneration by a train of Erk activity waves," Nature, Nature, vol. 590(7844), pages 129-133, February.
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