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Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions

Author

Listed:
  • Kimberly L. Cooper

    (Harvard Medical School)

  • Seungeun Oh

    (Harvard Medical School)

  • Yongjin Sung

    (George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology)

  • Ramachandra R. Dasari

    (George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology)

  • Marc W. Kirschner

    (Harvard Medical School)

  • Clifford J. Tabin

    (Harvard Medical School)

Abstract

A microscopy study of the cellular basis of mammalian skeletal elongation in development and evolution reveals three phases of chondrocyte volume enlargement, including a phase of disproportionate fluid increase.

Suggested Citation

  • Kimberly L. Cooper & Seungeun Oh & Yongjin Sung & Ramachandra R. Dasari & Marc W. Kirschner & Clifford J. Tabin, 2013. "Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions," Nature, Nature, vol. 495(7441), pages 375-378, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11940
    DOI: 10.1038/nature11940
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    Cited by:

    1. Fenli Shao & Qianqian Liu & Yuyu Zhu & Zhidan Fan & Wenjun Chen & Shijia Liu & Xiaohui Li & Wenjie Guo & Gen-Sheng Feng & Haiguo Yu & Qiang Xu & Yang Sun, 2021. "Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Chee Ho H’ng & Shanika L. Amarasinghe & Boya Zhang & Hojin Chang & Xinli Qu & David R. Powell & Alberto Rosello-Diez, 2024. "Compensatory growth and recovery of cartilage cytoarchitecture after transient cell death in fetal mouse limbs," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Ana Escribano-Núñez & Frederique M. F. Cornelis & Astrid Roover & An Sermon & Frédéric Cailotto & Rik J. Lories & Silvia Monteagudo, 2024. "IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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