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Acoustofluidic-based therapeutic apheresis system

Author

Listed:
  • Mengxi Wu

    (Dalian University of Technology
    Duke University)

  • Zhiteng Ma

    (Duke University)

  • Xianchen Xu

    (Duke University)

  • Brandon Lu

    (Duke University)

  • Yuyang Gu

    (Duke University)

  • Janghoon Yoon

    (Duke University Medical Center)

  • Jianping Xia

    (Duke University)

  • Zhehan Ma

    (Duke University)

  • Neil Upreti

    (Duke University)

  • Imran J. Anwar

    (Duke University Medical Center)

  • Stuart J. Knechtle

    (Duke University Medical Center)

  • Eileen T. Chambers

    (Duke University Medical Center)

  • Jean Kwun

    (Duke University Medical Center)

  • Luke P. Lee

    (Brigham and Women’s Hospital
    Berkeley
    University of California, Berkeley
    Sungkyunkwan University)

  • Tony Jun Huang

    (Duke University)

Abstract

Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients.

Suggested Citation

  • Mengxi Wu & Zhiteng Ma & Xianchen Xu & Brandon Lu & Yuyang Gu & Janghoon Yoon & Jianping Xia & Zhehan Ma & Neil Upreti & Imran J. Anwar & Stuart J. Knechtle & Eileen T. Chambers & Jean Kwun & Luke P. , 2024. "Acoustofluidic-based therapeutic apheresis system," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50053-1
    DOI: 10.1038/s41467-024-50053-1
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    References listed on IDEAS

    as
    1. Joseph Rufo & Peiran Zhang & Ruoyu Zhong & Luke P. Lee & Tony Jun Huang, 2022. "A sound approach to advancing healthcare systems: the future of biomedical acoustics," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. David J. Collins & Belinda Morahan & Jose Garcia-Bustos & Christian Doerig & Magdalena Plebanski & Adrian Neild, 2015. "Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

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