IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-49461-0.html
   My bibliography  Save this article

Precision arbovirus serology with a pan-arbovirus peptidome

Author

Listed:
  • William R. Morgenlander

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Wan Ni Chia

    (Program in Emerging Infectious Diseases Duke-NUS Medical School)

  • Beatriz Parra

    (Universidad del Valle)

  • Daniel R. Monaco

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Izabela Ragan

    (Colorado State University College of Veterinary and Biomedical Sciences)

  • Carlos A. Pardo

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Richard Bowen

    (Colorado State University College of Veterinary and Biomedical Sciences)

  • Diana Zhong

    (Johns Hopkins University School of Medicine)

  • Douglas E. Norris

    (Johns Hopkins University Bloomberg School of Public Health)

  • Ingo Ruczinski

    (Johns Hopkins University Bloomberg School of Public Health)

  • Anna Durbin

    (Johns Hopkins University Bloomberg School of Public Health)

  • Lin-Fa Wang

    (Program in Emerging Infectious Diseases Duke-NUS Medical School)

  • H. Benjamin Larman

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Matthew L. Robinson

    (Johns Hopkins University School of Medicine)

Abstract

Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or incapable of distinguishing closely related viruses, and many zoonotic arboviruses that may transition to humans lack any serologic assays. In this study, we present a programmable phage display platform, ArboScan, that evaluates antibody binding to overlapping peptides that represent the proteomes of 691 human and zoonotic arboviruses. We confirm that ArboScan provides detailed antibody binding information from animal sera, human sera, and an arthropod blood meal. ArboScan identifies distinguishing features of antibody responses based on exposure history in a Colombian cohort of Zika patients. Finally, ArboScan details epitope level information that rapidly identifies candidate epitopes with potential protective significance. ArboScan thus represents a resource for characterizing human and animal arbovirus antibody responses at cohort scale.

Suggested Citation

  • William R. Morgenlander & Wan Ni Chia & Beatriz Parra & Daniel R. Monaco & Izabela Ragan & Carlos A. Pardo & Richard Bowen & Diana Zhong & Douglas E. Norris & Ingo Ruczinski & Anna Durbin & Lin-Fa Wan, 2024. "Precision arbovirus serology with a pan-arbovirus peptidome," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49461-0
    DOI: 10.1038/s41467-024-49461-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-49461-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-49461-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Samir Bhatt & Peter W. Gething & Oliver J. Brady & Jane P. Messina & Andrew W. Farlow & Catherine L. Moyes & John M. Drake & John S. Brownstein & Anne G. Hoen & Osman Sankoh & Monica F. Myers & Dylan , 2013. "The global distribution and burden of dengue," Nature, Nature, vol. 496(7446), pages 504-507, April.
    2. Kate E. Jones & Nikkita G. Patel & Marc A. Levy & Adam Storeygard & Deborah Balk & John L. Gittleman & Peter Daszak, 2008. "Global trends in emerging infectious diseases," Nature, Nature, vol. 451(7181), pages 990-993, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jan C. Semenza, 2015. "Prototype Early Warning Systems for Vector-Borne Diseases in Europe," IJERPH, MDPI, vol. 12(6), pages 1-19, June.
    2. Yusuf Amuda Tajudeen & Habeebullah Jayeola Oladipo & Iyiola Olatunji Oladunjoye & Mutiat Oluwakemi Mustapha & Sheriff Taye Mustapha & Adam Aberi Abdullahi & Rashidat Onyinoyi Yusuf & Samuel Olushola A, 2022. "Preventing the Next Pandemic through a Planetary Health Approach: A Focus on Key Drivers of Zoonosis," Challenges, MDPI, vol. 13(2), pages 1-14, September.
    3. Marieta Braks & Rijk Van Ginkel & William Wint & Luigi Sedda & Hein Sprong, 2013. "Climate Change and Public Health Policy: Translating the Science," IJERPH, MDPI, vol. 11(1), pages 1-17, December.
    4. Çiğdem Ak & Önder Ergönül & İrfan Şencan & Mehmet Ali Torunoğlu & Mehmet Gönen, 2018. "Spatiotemporal prediction of infectious diseases using structured Gaussian processes with application to Crimean–Congo hemorrhagic fever," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 12(8), pages 1-20, August.
    5. Nikolett Orosz & Tünde Tóthné Tóth & Gyöngyi Vargáné Gyuró & Zsoltné Tibor Nábrádi & Klára Hegedűsné Sorosi & Zsuzsa Nagy & Éva Rigó & Ádám Kaposi & Gabriella Gömöri & Cornelia Melinda Adi Santoso & A, 2022. "Comparison of Length of Hospital Stay for Community-Acquired Infections Due to Enteric Pathogens, Influenza Viruses and Multidrug-Resistant Bacteria: A Cross-Sectional Study in Hungary," IJERPH, MDPI, vol. 19(23), pages 1-16, November.
    6. World Bank, 2024. "Toward a One Health Approach in Sudan," World Bank Publications - Reports 41580, The World Bank Group.
    7. Ceddia, M.G. & Bardsley, N.O. & Goodwin, R. & Holloway, G.J. & Nocella, G. & Stasi, A., 2013. "A complex system perspective on the emergence and spread of infectious diseases: Integrating economic and ecological aspects," Ecological Economics, Elsevier, vol. 90(C), pages 124-131.
    8. Eunha Shim, 2017. "Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-17, April.
    9. Livia Marchetti & Valentina Cattivelli & Claudia Cocozza & Fabio Salbitano & Marco Marchetti, 2020. "Beyond Sustainability in Food Systems: Perspectives from Agroecology and Social Innovation," Sustainability, MDPI, vol. 12(18), pages 1-24, September.
    10. Dominik Kiemel & Ann-Sophie Helene Kroell & Solène Denolly & Uta Haselmann & Jean-François Bonfanti & Jose Ignacio Andres & Brahma Ghosh & Peggy Geluykens & Suzanne J. F. Kaptein & Lucas Wilken & Piet, 2024. "Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    11. Maxwell B Joseph & William E Stutz & Pieter T J Johnson, 2016. "Multilevel Models for the Distribution of Hosts and Symbionts," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.
    12. Laure Bonnaud & Nicolas Fortané, 2017. "Serge Morand and Muriel Figuié (eds), 2016, Emergence de maladies infectieuses. Risques et enjeux de société (The emergence of infectious diseases. Societal risks and stakes)," Review of Agricultural, Food and Environmental Studies, Springer, vol. 98(3), pages 225-228, December.
    13. Chen, Xiaowei & Chong, Wing Fung & Feng, Runhuan & Zhang, Linfeng, 2021. "Pandemic risk management: Resources contingency planning and allocation," Insurance: Mathematics and Economics, Elsevier, vol. 101(PB), pages 359-383.
    14. Lin Zhang & Jason Rohr & Ruina Cui & Yusi Xin & Lixia Han & Xiaona Yang & Shimin Gu & Yuanbao Du & Jing Liang & Xuyu Wang & Zhengjun Wu & Qin Hao & Xuan Liu, 2022. "Biological invasions facilitate zoonotic disease emergences," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    15. Ricardo Aguas & Neil M Ferguson, 2013. "Feature Selection Methods for Identifying Genetic Determinants of Host Species in RNA Viruses," PLOS Computational Biology, Public Library of Science, vol. 9(10), pages 1-10, October.
    16. Katarzyna Kubiak & Hanna Szymańska & Małgorzata Dmitryjuk & Ewa Dzika, 2022. "Abundance of Ixodes ricinus Ticks (Acari: Ixodidae) and the Diversity of Borrelia Species in Northeastern Poland," IJERPH, MDPI, vol. 19(12), pages 1-18, June.
    17. Cheng-Te Lin & Yu-Sheng Huang & Lu-Wen Liao & Chung-Te Ting, 2020. "Measuring Consumer Willingness to Pay to Reduce Health Risks of Contracting Dengue Fever," IJERPH, MDPI, vol. 17(5), pages 1-15, March.
    18. Amy R. Krystosik & Andrew Curtis & A. Desiree LaBeaud & Diana M. Dávalos & Robinson Pacheco & Paola Buritica & Álvaro A. Álvarez & Madhav P. Bhatta & Jorge Humberto Rojas Palacios & Mark A. James, 2018. "Neighborhood Violence Impacts Disease Control and Surveillance: Case Study of Cali, Colombia from 2014 to 2016," IJERPH, MDPI, vol. 15(10), pages 1-20, September.
    19. Luiza M Karpavicius & Ariaster Chimeli, 2023. "Forest Protection and Human Health: The Case of Malaria in the Brazilian Amazon," Working Papers, Department of Economics 2023_08, University of São Paulo (FEA-USP), revised 26 Jul 2023.
    20. Kranz, Johann & Zeiss, Roman & Beck, Roman & Gholami, Roya & Sarker, Saonee & Watson, Richard T. & Whitley, Edgar A., 2022. "Practicing what we preach? Reflections on more sustainable and responsible IS research and teaching practices," LSE Research Online Documents on Economics 116677, London School of Economics and Political Science, LSE Library.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49461-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.