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Precision arbovirus serology with a pan-arbovirus peptidome

Author

Listed:
  • William R. Morgenlander

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Wan Ni Chia

    (Program in Emerging Infectious Diseases Duke-NUS Medical School)

  • Beatriz Parra

    (Universidad del Valle)

  • Daniel R. Monaco

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Izabela Ragan

    (Colorado State University College of Veterinary and Biomedical Sciences)

  • Carlos A. Pardo

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Richard Bowen

    (Colorado State University College of Veterinary and Biomedical Sciences)

  • Diana Zhong

    (Johns Hopkins University School of Medicine)

  • Douglas E. Norris

    (Johns Hopkins University Bloomberg School of Public Health)

  • Ingo Ruczinski

    (Johns Hopkins University Bloomberg School of Public Health)

  • Anna Durbin

    (Johns Hopkins University Bloomberg School of Public Health)

  • Lin-Fa Wang

    (Program in Emerging Infectious Diseases Duke-NUS Medical School)

  • H. Benjamin Larman

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Matthew L. Robinson

    (Johns Hopkins University School of Medicine)

Abstract

Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or incapable of distinguishing closely related viruses, and many zoonotic arboviruses that may transition to humans lack any serologic assays. In this study, we present a programmable phage display platform, ArboScan, that evaluates antibody binding to overlapping peptides that represent the proteomes of 691 human and zoonotic arboviruses. We confirm that ArboScan provides detailed antibody binding information from animal sera, human sera, and an arthropod blood meal. ArboScan identifies distinguishing features of antibody responses based on exposure history in a Colombian cohort of Zika patients. Finally, ArboScan details epitope level information that rapidly identifies candidate epitopes with potential protective significance. ArboScan thus represents a resource for characterizing human and animal arbovirus antibody responses at cohort scale.

Suggested Citation

  • William R. Morgenlander & Wan Ni Chia & Beatriz Parra & Daniel R. Monaco & Izabela Ragan & Carlos A. Pardo & Richard Bowen & Diana Zhong & Douglas E. Norris & Ingo Ruczinski & Anna Durbin & Lin-Fa Wan, 2024. "Precision arbovirus serology with a pan-arbovirus peptidome," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49461-0
    DOI: 10.1038/s41467-024-49461-0
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    References listed on IDEAS

    as
    1. Samir Bhatt & Peter W. Gething & Oliver J. Brady & Jane P. Messina & Andrew W. Farlow & Catherine L. Moyes & John M. Drake & John S. Brownstein & Anne G. Hoen & Osman Sankoh & Monica F. Myers & Dylan , 2013. "The global distribution and burden of dengue," Nature, Nature, vol. 496(7446), pages 504-507, April.
    2. Kate E. Jones & Nikkita G. Patel & Marc A. Levy & Adam Storeygard & Deborah Balk & John L. Gittleman & Peter Daszak, 2008. "Global trends in emerging infectious diseases," Nature, Nature, vol. 451(7181), pages 990-993, February.
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