IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-49348-0.html
   My bibliography  Save this article

SOD3 suppresses early cellular immune responses to parasite infection

Author

Listed:
  • Qilong Li

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Kunying Lv

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Ning Jiang

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Tong Liu

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Nan Hou

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Liying Yu

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Yixin Yang

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Anni Feng

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Yiwei Zhang

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Ziwei Su

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Xiaoyu Sang

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Ying Feng

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Ran Chen

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

  • Wenyue Xu

    (Army Medical University (Third Military Medical University))

  • Liwang Cui

    (University of South Florida)

  • Yaming Cao

    (China Medical University)

  • Qijun Chen

    (Shenyang Agricultural University
    Chinese Academy of Medical Sciences)

Abstract

Host immune responses are tightly controlled by various immune factors during infection, and protozoan parasites also manipulate the immune system to evade surveillance, leading to an evolutionary arms race in host‒pathogen interactions; however, the underlying mechanisms are not fully understood. We observed that the level of superoxide dismutase 3 (SOD3) was significantly elevated in both Plasmodium falciparum malaria patients and mice infected with four parasite species. SOD3-deficient mice had a substantially longer survival time and lower parasitemia than control mice after infection, whereas SOD3-overexpressing mice were much more vulnerable to parasite infection. We revealed that SOD3, secreted from activated neutrophils, bound to T cells, suppressed the interleukin-2 expression and concomitant interferon-gamma responses crucial for parasite clearance. Overall, our findings expose active fronts in the arms race between the parasites and host immune system and provide insights into the roles of SOD3 in shaping host innate immune responses to parasite infection.

Suggested Citation

  • Qilong Li & Kunying Lv & Ning Jiang & Tong Liu & Nan Hou & Liying Yu & Yixin Yang & Anni Feng & Yiwei Zhang & Ziwei Su & Xiaoyu Sang & Ying Feng & Ran Chen & Wenyue Xu & Liwang Cui & Yaming Cao & Qiju, 2024. "SOD3 suppresses early cellular immune responses to parasite infection," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49348-0
    DOI: 10.1038/s41467-024-49348-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-49348-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-49348-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tobias Sahr & Pedro Escoll & Christophe Rusniok & Sheryl Bui & Gérard Pehau-Arnaudet & Gregory Lavieu & Carmen Buchrieser, 2022. "Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Zhiguang Chang & Ning Jiang & Yuanyuan Zhang & Huijun Lu & Jigang Yin & Mats Wahlgren & Xunjia Cheng & Yaming Cao & Qijun Chen, 2016. "The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    3. Qijun Chen & Victor Fernandez & Annika Sundström & Martha Schlichtherle & Santanu Datta & Per Hagblom & Mats Wahlgren, 1998. "Developmental selection of var gene expression in Plasmodium falciparum," Nature, Nature, vol. 394(6691), pages 392-395, July.
    4. Andrea Ablasser & Jonathan L. Schmid-Burgk & Inga Hemmerling & Gabor L. Horvath & Tobias Schmidt & Eicke Latz & Veit Hornung, 2013. "Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP," Nature, Nature, vol. 503(7477), pages 530-534, November.
    5. Louis H. Miller & Dror I. Baruch & Kevin Marsh & Ogobara K. Doumbo, 2002. "The pathogenic basis of malaria," Nature, Nature, vol. 415(6872), pages 673-679, February.
    6. Julie Joseph & Emmanuelle S. Ametepe & Naveen Haribabu & Gerard Agbayani & Lakshmi Krishnan & Alexandre Blais & Subash Sad, 2016. "Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium," Nature Communications, Nature, vol. 7(1), pages 1-14, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xingxing Ren & Qiuyuan Liu & Peirong Zhou & Tingyue Zhou & Decai Wang & Qiao Mei & Richard A. Flavell & Zhanju Liu & Mingsong Li & Wen Pan & Shu Zhu, 2024. "DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Tomalika R. Ullah & Matt D. Johansen & Katherine R. Balka & Rebecca L. Ambrose & Linden J. Gearing & James Roest & Julian P. Vivian & Sunil Sapkota & W. Samantha N. Jayasekara & Daniel S. Wenholz & Vi, 2023. "Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Ping Chun Wu & Yan Quan Lee & Mattias Möller & Jill R. Storry & Martin L. Olsson, 2023. "Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Titus Okello Orwa & Rachel Waema Mbogo & Livingstone Serwadda Luboobi, 2018. "Mathematical Model for Hepatocytic-Erythrocytic Dynamics of Malaria," International Journal of Mathematics and Mathematical Sciences, Hindawi, vol. 2018, pages 1-18, July.
    5. Rahul Sharma & Michael Adams & Simonne Griffith-Jones & Tobias Sahr & Laura Gomez-Valero & Felix Weis & Michael Hons & Sarah Gharbi & Rayene Berkane & Alexandra Stolz & Carmen Buchrieser & Sagar Bhoga, 2023. "Structural basis for the toxicity of Legionella pneumophila effector SidH," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Chen, Hongyan & Wang, Wendi & Fu, Rui & Luo, Jianfeng, 2015. "Global analysis of a mathematical model on malaria with competitive strains and immune responses," Applied Mathematics and Computation, Elsevier, vol. 259(C), pages 132-152.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49348-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.