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The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate

Author

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  • Zhiguang Chang

    (Key Laboratory of Zoonosis, Jilin University)

  • Ning Jiang

    (Key Laboratory of Zoonosis, Jilin University)

  • Yuanyuan Zhang

    (Key Laboratory of Zoonosis, Jilin University)

  • Huijun Lu

    (Key Laboratory of Zoonosis, Jilin University)

  • Jigang Yin

    (Key Laboratory of Zoonosis, Jilin University)

  • Mats Wahlgren

    (Institute of Microbiology, Tumour and Cellular Biology, Karolinska Institutet)

  • Xunjia Cheng

    (Fudan University)

  • Yaming Cao

    (China Medical University)

  • Qijun Chen

    (Key Laboratory of Zoonosis, Jilin University
    Institute of Microbiology, Tumour and Cellular Biology, Karolinska Institutet
    Key Laboratory of Zoonosis, Shenyang Agricultural University)

Abstract

Neutrophil extracellular traps (NETs), composed primarily of DNA and proteases, are released from activated neutrophils and contribute to the innate immune response by capturing pathogens. Plasmodium falciparum, the causative agent of severe malaria, thrives in its host by counteracting immune elimination. Here, we report the discovery of a novel virulence factor of P. falciparum, a TatD-like DNase (PfTatD) that is expressed primarily in the asexual blood stage and is likely utilized by the parasite to counteract NETs. PfTatD exhibits typical deoxyribonuclease activity, and its expression is higher in virulent parasites than in avirulent parasites. A P. berghei TatD-knockout parasite displays reduced pathogenicity in mice. Mice immunized with recombinant TatD exhibit increased immunity against lethal challenge. Our results suggest that the TatD-like DNase is an essential factor for the survival of malarial parasites in the host and is a potential malaria vaccine candidate.

Suggested Citation

  • Zhiguang Chang & Ning Jiang & Yuanyuan Zhang & Huijun Lu & Jigang Yin & Mats Wahlgren & Xunjia Cheng & Yaming Cao & Qijun Chen, 2016. "The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11537
    DOI: 10.1038/ncomms11537
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    Cited by:

    1. Qilong Li & Kunying Lv & Ning Jiang & Tong Liu & Nan Hou & Liying Yu & Yixin Yang & Anni Feng & Yiwei Zhang & Ziwei Su & Xiaoyu Sang & Ying Feng & Ran Chen & Wenyue Xu & Liwang Cui & Yaming Cao & Qiju, 2024. "SOD3 suppresses early cellular immune responses to parasite infection," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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