IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-49283-0.html
   My bibliography  Save this article

Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics

Author

Listed:
  • Fan Pu

    (Zhejiang University School of Medicine)

  • Weiran Chen

    (Zhejiang University School of Medicine)

  • Chenxi Li

    (Zhejiang University School of Medicine)

  • Jingqiao Fu

    (Zhejiang University)

  • Weijing Gao

    (Zhejiang University School of Medicine)

  • Chao Ma

    (Southeast University)

  • Xingqi Cao

    (Zhejiang University School of Medicine)

  • Lingzhi Zhang

    (Zhejiang University School of Medicine)

  • Meng Hao

    (Fudan University)

  • Jin Zhou

    (China Medical University)

  • Rong Huang

    (China Medical University)

  • Yanan Ma

    (China Medical University)

  • Kejia Hu

    (Zhejiang University School of Medicine)

  • Zuyun Liu

    (Zhejiang University School of Medicine)

Abstract

Complicated associations between multiplexed environmental factors and aging are poorly understood. We manipulated aging using multidimensional metrics such as phenotypic age, brain age, and brain volumes in the UK Biobank. Weighted quantile sum regression was used to examine the relative individual contributions of multiplexed environmental factors to aging, and self-organizing maps (SOMs) were used to examine joint effects. Air pollution presented a relatively large contribution in most cases. We also found fair heterogeneities in which the same environmental factor contributed inconsistently to different aging metrics. Particulate matter contributed the most to variance in aging, while noise and green space showed considerable contribution to brain volumes. SOM identified five subpopulations with distinct environmental exposure patterns and the air pollution subpopulation had the worst aging status. This study reveals the heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics and serves as a proof of concept when analyzing multifactors and multiple outcomes.

Suggested Citation

  • Fan Pu & Weiran Chen & Chenxi Li & Jingqiao Fu & Weijing Gao & Chao Ma & Xingqi Cao & Lingzhi Zhang & Meng Hao & Jin Zhou & Rong Huang & Yanan Ma & Kejia Hu & Zuyun Liu, 2024. "Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49283-0
    DOI: 10.1038/s41467-024-49283-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-49283-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-49283-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Louis-François Tétreault & Stéphane Perron & Audrey Smargiassi, 2013. "Cardiovascular health, traffic-related air pollution and noise: are associations mutually confounded? A systematic review," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 58(5), pages 649-666, October.
    2. Zuyun Liu & Pei-Lun Kuo & Steve Horvath & Eileen Crimmins & Luigi Ferrucci & Morgan Levine, 2018. "A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study," PLOS Medicine, Public Library of Science, vol. 15(12), pages 1-20, December.
    3. Zuyun Liu & Xi Chen & Thomas M Gill & Chao Ma & Eileen M Crimmins & Morgan E Levine, 2019. "Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study," PLOS Medicine, Public Library of Science, vol. 16(6), pages 1-22, June.
    4. Julie Gonneaud & Alex T. Baria & Alexa Pichet Binette & Brian A. Gordon & Jasmeer P. Chhatwal & Carlos Cruchaga & Mathias Jucker & Johannes Levin & Stephen Salloway & Martin Farlow & Serge Gauthier & , 2021. "Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xu Gao & Tong Geng & Meijie Jiang & Ninghao Huang & Yinan Zheng & Daniel W. Belsky & Tao Huang, 2023. "Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Chen, Xi, 2022. "Early Life Circumstances and the Health of Older Adults: A Research Note," GLO Discussion Paper Series 1158, Global Labor Organization (GLO).
    3. Ikenna C. Eze & Medea Imboden & Maria Foraster & Emmanuel Schaffner & Ashish Kumar & Danielle Vienneau & Harris Héritier & Franziska Rudzik & Laurie Thiesse & Reto Pieren & Arnold Von Eckardstein & Ch, 2017. "Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults," IJERPH, MDPI, vol. 14(12), pages 1-18, December.
    4. Owen Douglas & Enda Murphy, 2020. "Assessing the Treatment of Potential Effect Modifiers Informing World Health Organisation Guidelines for Environmental Noise," IJERPH, MDPI, vol. 17(1), pages 1-17, January.
    5. Luc Dekoninck & Dick Botteldooren & Luc Int Panis, 2017. "Extending Participatory Sensing to Personal Exposure Using Microscopic Land Use Regression Models," IJERPH, MDPI, vol. 14(6), pages 1-17, May.
    6. Enembe O. Okokon & Tarja Yli-Tuomi & Taina Siponen & Pekka Tiittanen & Anu W. Turunen & Leena Kangas & Ari Karppinen & Jaakko Kukkonen & Timo Lanki, 2021. "Heterogeneous Urban Exposures and Prevalent Hypertension in the Helsinki Capital Region, Finland," IJERPH, MDPI, vol. 18(3), pages 1-14, January.
    7. Stephen A. Stansfeld, 2015. "Noise Effects on Health in the Context of Air Pollution Exposure," IJERPH, MDPI, vol. 12(10), pages 1-26, October.
    8. Marcus Hedblom & Bengt Gunnarsson & Martin Schaefer & Igor Knez & Pontus Thorsson & Johan N. Lundström, 2019. "Sounds of Nature in the City: No Evidence of Bird Song Improving Stress Recovery," IJERPH, MDPI, vol. 16(8), pages 1-12, April.
    9. Yee Xing You & Nurul Fatin Malek Rivan & Devinder Kaur Ajit Singh & Nor Fadilah Rajab & Arimi Fitri Mat Ludin & Normah Che Din & Ai-Vyrn Chin & Michael Fenech & Mohd Zul Amin Kamaruddin & Suzana Shaha, 2022. "Incidence and Predictors of Mortality among Community-Dwelling Older Adults in Malaysia: A 5 Years Longitudinal Study," IJERPH, MDPI, vol. 19(15), pages 1-16, July.
    10. Maria Foraster, 2013. "Is it traffic-related air pollution or road traffic noise, or both? Key questions not yet settled!," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 58(5), pages 647-648, October.
    11. Nino Künzli, 2013. "IJPH goes environmental: does it?," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 58(5), pages 643-644, October.
    12. Rafael Timon & Adrián González-Custodio & Aldo Vasquez-Bonilla & Guillermo Olcina & Alejo Leal, 2022. "Intermittent Hypoxia as a Therapeutic Tool to Improve Health Parameters in Older Adults," IJERPH, MDPI, vol. 19(9), pages 1-9, April.
    13. Kwan, Soo Chen & Ismail, Rohaida & Ismail, Nor Halizam & Mohamed, Norlen, 2021. "An ecological study of the relationship between urban built environment and cardiovascular hospital admissions (2004–2016) in an Asian developing country," Social Science & Medicine, Elsevier, vol. 276(C).
    14. Olivier Chanel & Laura Perez & Nino Künzli & Sylvia Medina, 2016. "The hidden economic burden of air pollution-related morbidity: evidence from the Aphekom project," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(9), pages 1101-1115, December.
    15. Elise Van Kempen & Maribel Casas & Göran Pershagen & Maria Foraster, 2018. "WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Cardiovascular and Metabolic Effects: A Summary," IJERPH, MDPI, vol. 15(2), pages 1-59, February.
    16. Lindgren, Samuel, 2021. "A sound environment: health effects of traffic noise mitigation," Working Papers 2021:10, Swedish National Road & Transport Research Institute (VTI).
    17. Mladen Miletić & Edouard Ivanjko & Tomislav Fratrović & Borna Abramović, 2023. "Air Pollution Modeling for Sustainable Urban Mobility with COVID-19 Impact Analysis: Case Study of Skopje," Sustainability, MDPI, vol. 15(2), pages 1-21, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49283-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.