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KSHV infection of B cells primes protective T cell responses in humanized mice

Author

Listed:
  • Nicole Caduff

    (University of Zürich
    1 DNA Way)

  • Lisa Rieble

    (University of Zürich)

  • Michelle Böni

    (University of Zürich)

  • Donal McHugh

    (University of Zürich
    Medical Department)

  • Romin Roshan

    (Frederick National Laboratory for Cancer Research)

  • Wendell Miley

    (Frederick National Laboratory for Cancer Research)

  • Nazzarena Labo

    (Frederick National Laboratory for Cancer Research)

  • Sumanta Barman

    (Heinrich Heine University Düsseldorf)

  • Matthew Trivett

    (Frederick National Laboratory for Cancer Research)

  • Douwe M. T. Bosma

    (University of Zürich
    Leiden University Medical Center)

  • Julia Rühl

    (University of Zürich)

  • Norbert Goebels

    (Heinrich Heine University Düsseldorf)

  • Denise Whitby

    (Frederick National Laboratory for Cancer Research)

  • Christian Münz

    (University of Zürich)

Abstract

Kaposi sarcoma associated herpesvirus (KSHV) is associated with around 1% of all human tumors, including the B cell malignancy primary effusion lymphoma (PEL), in which co-infection with the Epstein Barr virus (EBV) can almost always be found in malignant cells. Here, we demonstrate that KSHV/EBV co-infection of mice with reconstituted human immune systems (humanized mice) leads to IgM responses against both latent and lytic KSHV antigens, and expansion of central and effector memory CD4+ and CD8+ T cells. Among these, KSHV/EBV dual-infection allows for the priming of CD8+ T cells that are specific for the lytic KSHV antigen K6 and able to kill KSHV/EBV infected B cells. This suggests that K6 may represent a vaccine antigen for the control of KSHV and its associated pathologies in high seroprevalence regions, such as Sub-Saharan Africa.

Suggested Citation

  • Nicole Caduff & Lisa Rieble & Michelle Böni & Donal McHugh & Romin Roshan & Wendell Miley & Nazzarena Labo & Sumanta Barman & Matthew Trivett & Douwe M. T. Bosma & Julia Rühl & Norbert Goebels & Denis, 2024. "KSHV infection of B cells primes protective T cell responses in humanized mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49209-w
    DOI: 10.1038/s41467-024-49209-w
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    References listed on IDEAS

    as
    1. Angela Nalwoga & Romin Roshan & Kyle Moore & Vickie Marshall & Wendell Miley & Nazzarena Labo & Marjorie Nakibuule & Stephen Cose & Rosemary Rochford & Robert Newton & Denise Whitby, 2021. "Kaposi’s sarcoma-associated herpesvirus T cell responses in HIV seronegative individuals from rural Uganda," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    2. Mikhail Shugay & Dmitriy V Bagaev & Maria A Turchaninova & Dmitriy A Bolotin & Olga V Britanova & Ekaterina V Putintseva & Mikhail V Pogorelyy & Vadim I Nazarov & Ivan V Zvyagin & Vitalina I Kirgizova, 2015. "VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires," PLOS Computational Biology, Public Library of Science, vol. 11(11), pages 1-16, November.
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