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Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study

Author

Listed:
  • Diana Dunca

    (University College London
    University College London)

  • Sandesh Chopade

    (University College London)

  • María Gordillo-Marañón

    (University College London)

  • Aroon D. Hingorani

    (University College London
    UCL British Heart Foundation Research Accelerator
    Health Data Research UK)

  • Karoline Kuchenbaecker

    (University College London
    University College London)

  • Chris Finan

    (University College London
    UCL British Heart Foundation Research Accelerator
    Health Data Research UK)

  • Amand F. Schmidt

    (University College London
    UCL British Heart Foundation Research Accelerator
    Amsterdam UMC Heart Center)

Abstract

CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C) and lack of drug target Mendelian randomization (MR) effect on CHD as evidence that CETP inhibitors might not be effective in East Asian participants. Capitalizing on recent increases in sample size of East Asian genetic studies, we conducted a drug target MR analysis, scaled to a standard deviation increase in high-density lipoprotein cholesterol. Despite finding evidence for possible neutral effects of lower CETP levels on LDL-C, systolic blood pressure and pulse pressure in East Asians (interaction p-values

Suggested Citation

  • Diana Dunca & Sandesh Chopade & María Gordillo-Marañón & Aroon D. Hingorani & Karoline Kuchenbaecker & Chris Finan & Amand F. Schmidt, 2024. "Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49109-z
    DOI: 10.1038/s41467-024-49109-z
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