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A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment

Author

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  • Stefano Vanni

    (Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis and Centre National de la Recherche Scientifique, UMR 7275)

  • Hisaaki Hirose

    (Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis and Centre National de la Recherche Scientifique, UMR 7275)

  • Hélène Barelli

    (Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis and Centre National de la Recherche Scientifique, UMR 7275)

  • Bruno Antonny

    (Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis and Centre National de la Recherche Scientifique, UMR 7275)

  • Romain Gautier

    (Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis and Centre National de la Recherche Scientifique, UMR 7275)

Abstract

Two parameters of biological membranes, curvature and lipid composition, direct the recruitment of many peripheral proteins to cellular organelles. Although these traits are often studied independently, it is their combination that generates the unique interfacial properties of cellular membranes. Here, we use a combination of in vivo, in vitro and in silico approaches to provide a comprehensive map of how these parameters modulate membrane adhesive properties. The correlation between the membrane partitioning of model amphipathic helices and the distribution of lipid-packing defects in membranes of different shape and composition explains how macroscopic membrane properties modulate protein recruitment by changing the molecular topography of the membrane interfacial region. Furthermore, our results suggest that the range of conditions that can be obtained in a cellular context is remarkably large because lipid composition and curvature have, under most circumstances, cumulative effects.

Suggested Citation

  • Stefano Vanni & Hisaaki Hirose & Hélène Barelli & Bruno Antonny & Romain Gautier, 2014. "A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5916
    DOI: 10.1038/ncomms5916
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    Cited by:

    1. Alexia Stollmann & Jose Garcia-Guirado & Jae-Sang Hong & Pascal Rüedi & Hyungsoon Im & Hakho Lee & Jaime Ortega Arroyo & Romain Quidant, 2024. "Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Yong Mi Choi & Dalila Ajjaji & Kaelin D. Fleming & Peter P. Borbat & Meredith L. Jenkins & Brandon E. Moeller & Shaveen Fernando & Surita R. Bhatia & Jack H. Freed & John E. Burke & Abdou Rachid Thiam, 2023. "Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Maria Osetrova & Anna Tkachev & Waltraud Mair & Patricia Guijarro Larraz & Olga Efimova & Ilia Kurochkin & Elena Stekolshchikova & Nickolay Anikanov & Juat Chin Foo & Amaury Cazenave-Gassiot & Aleksan, 2024. "Lipidome atlas of the adult human brain," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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