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Fused in sarcoma (FUS) inhibits milk production efficiency in mammals

Author

Listed:
  • Haili Shao

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Jipeng Huang

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Hui Wang

    (Chinese Academy of Sciences)

  • Guolei Wang

    (Weifang People’s Hospital)

  • Xu Yang

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Mei Cheng

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Changjie Sun

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Li Zou

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Qin Yang

    (Chinese Academy of Sciences)

  • Dandan Zhang

    (Luoyang Maternal and Child Health Hospital)

  • Zhen Liu

    (Chinese Academy of Sciences)

  • Xuelong Jiang

    (Chinese Academy of Sciences)

  • Lei Shi

    (Chinese Academy of Sciences)

  • Peng Shi

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Baowei Han

    (Luoyang Maternal and Child Health Hospital)

  • Baowei Jiao

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

Abstract

Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals, from marsupials to eutherians, remains elusive. Here, we find that mammary gland of the marsupial sugar glider contained milk components during adolescence, and that mammary gland development is less dynamically cyclic compared to that in placental mammals. Furthermore, fused in sarcoma (FUS) is found to be partially responsible for this establishment of low efficiency. In mouse model, FUS inhibit mammary epithelial cell differentiation through the cyclin-dependent kinase inhibitor p57Kip2, leading to lactation failure and pup starvation. Clinically, FUS levels are negatively correlated with milk production in lactating women. Overall, our results shed light on FUS as a negative regulator of milk production, providing a potential mechanism for the establishment of milk production from marsupial to eutherian mammals.

Suggested Citation

  • Haili Shao & Jipeng Huang & Hui Wang & Guolei Wang & Xu Yang & Mei Cheng & Changjie Sun & Li Zou & Qin Yang & Dandan Zhang & Zhen Liu & Xuelong Jiang & Lei Shi & Peng Shi & Baowei Han & Baowei Jiao, 2024. "Fused in sarcoma (FUS) inhibits milk production efficiency in mammals," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48428-5
    DOI: 10.1038/s41467-024-48428-5
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    2. Carson C. Thoreen & Lynne Chantranupong & Heather R. Keys & Tim Wang & Nathanael S. Gray & David M. Sabatini, 2012. "A unifying model for mTORC1-mediated regulation of mRNA translation," Nature, Nature, vol. 485(7396), pages 109-113, May.
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