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A unifying model for mTORC1-mediated regulation of mRNA translation

Author

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  • Carson C. Thoreen

    (Dana Farber Cancer Institute, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
    Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Lynne Chantranupong

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center)

  • Heather R. Keys

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center)

  • Tim Wang

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology)

  • Nathanael S. Gray

    (Dana Farber Cancer Institute, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT, Seven Cambridge Center)

Abstract

mTORC1 is shown to regulate a translational program that requires the rapamycin-resistant 4E-BP family of translational repressors and consists almost entirely of mRNAs containing 5′ terminal oligopyrimidine or related motifs.

Suggested Citation

  • Carson C. Thoreen & Lynne Chantranupong & Heather R. Keys & Tim Wang & Nathanael S. Gray & David M. Sabatini, 2012. "A unifying model for mTORC1-mediated regulation of mRNA translation," Nature, Nature, vol. 485(7396), pages 109-113, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7396:d:10.1038_nature11083
    DOI: 10.1038/nature11083
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    Cited by:

    1. Melvin Pan & Christiane Zorbas & Maki Sugaya & Kensuke Ishiguro & Miki Kato & Miyuki Nishida & Hai-Feng Zhang & Marco M. Candeias & Akimitsu Okamoto & Takamasa Ishikawa & Tomoyoshi Soga & Hiroyuki Abu, 2022. "Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Fiamma Salerno & Andrew J. M. Howden & Louise S. Matheson & Özge Gizlenci & Michael Screen & Holger Lingel & Monika C. Brunner-Weinzierl & Martin Turner, 2023. "An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Kathrin Leppek & Gun Woo Byeon & Wipapat Kladwang & Hannah K. Wayment-Steele & Craig H. Kerr & Adele F. Xu & Do Soon Kim & Ved V. Topkar & Christian Choe & Daphna Rothschild & Gerald C. Tiu & Roger We, 2022. "Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. Fajin Li & Jianhuo Fang & Yifan Yu & Sijia Hao & Qin Zou & Qinglin Zeng & Xuerui Yang, 2023. "Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Tal Levy & Kai Voeltzke & Laura Hruby & Khawla Alasad & Zuelal Bas & Marteinn Snaebjörnsson & Ran Marciano & Katerina Scharov & Mélanie Planque & Kim Vriens & Stefan Christen & Cornelius M. Funk & Chr, 2024. "mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Haili Shao & Jipeng Huang & Hui Wang & Guolei Wang & Xu Yang & Mei Cheng & Changjie Sun & Li Zou & Qin Yang & Dandan Zhang & Zhen Liu & Xuelong Jiang & Lei Shi & Peng Shi & Baowei Han & Baowei Jiao, 2024. "Fused in sarcoma (FUS) inhibits milk production efficiency in mammals," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Elisenda Sanz & Ryan Evanoff & Albert Quintana & Elizabeth Evans & Jeremy A Miller & Chemyong Ko & Paul S Amieux & Michael D Griswold & G Stanley McKnight, 2013. "RiboTag Analysis of Actively Translated mRNAs in Sertoli and Leydig Cells In Vivo," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-16, June.

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