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Rapid and on-site wireless immunoassay of respiratory virus aerosols via hydrogel-modulated resonators

Author

Listed:
  • Xin Li

    (Zhejiang University
    Research Institute of Zhejiang University-Taizhou)

  • Rujing Sun

    (Zhejiang University
    Guangxi Medical University)

  • Jingying Pan

    (Zhejiang University
    Zhejiang University)

  • Zhenghan Shi

    (Zhejiang University)

  • Zijian An

    (Zhejiang University)

  • Chaobo Dai

    (Zhejiang University)

  • Jingjiang Lv

    (Zhejiang University)

  • Guang Liu

    (Zhejiang University)

  • Hao Liang

    (Guangxi Medical University)

  • Jun Liu

    (Zhejiang University
    Research Institute of Zhejiang University-Taizhou)

  • Yanli Lu

    (Zhejiang University
    Zhejiang Lab)

  • Fenni Zhang

    (Zhejiang University)

  • Qingjun Liu

    (Zhejiang University
    Research Institute of Zhejiang University-Taizhou)

Abstract

Rapid and accurate detection of respiratory virus aerosols is highlighted for virus surveillance and infection control. Here, we report a wireless immunoassay technology for fast (within 10 min), on-site (wireless and battery-free), and sensitive (limit of detection down to fg/L) detection of virus antigens in aerosols. The wireless immunoassay leverages the immuno-responsive hydrogel-modulated radio frequency resonant sensor to capture and amplify the recognition of virus antigen, and flexible readout network to transduce the immuno bindings into electrical signals. The wireless immunoassay achieves simultaneous detection of respiratory viruses such as severe acute respiratory syndrome coronavirus 2, influenza A H1N1 virus, and respiratory syncytial virus for community infection surveillance. Direct detection of unpretreated clinical samples further demonstrates high accuracy for diagnosis of respiratory virus infection. This work provides a sensitive and accurate immunoassay technology for on-site virus detection and disease diagnosis compatible with wearable integration.

Suggested Citation

  • Xin Li & Rujing Sun & Jingying Pan & Zhenghan Shi & Zijian An & Chaobo Dai & Jingjiang Lv & Guang Liu & Hao Liang & Jun Liu & Yanli Lu & Fenni Zhang & Qingjun Liu, 2024. "Rapid and on-site wireless immunoassay of respiratory virus aerosols via hydrogel-modulated resonators," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48294-1
    DOI: 10.1038/s41467-024-48294-1
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    References listed on IDEAS

    as
    1. Takashi Miyata & Noriko Asami & Tadashi Uragami, 1999. "A reversibly antigen-responsive hydrogel," Nature, Nature, vol. 399(6738), pages 766-769, June.
    2. Rongzhou Lin & Han-Joon Kim & Sippanat Achavananthadith & Selman A. Kurt & Shawn C. C. Tan & Haicheng Yao & Benjamin C. K. Tee & Jason K. W. Lee & John S. Ho, 2020. "Wireless battery-free body sensor networks using near-field-enabled clothing," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    3. Manu S. Mannoor & Hu Tao & Jefferson D. Clayton & Amartya Sengupta & David L. Kaplan & Rajesh R. Naik & Naveen Verma & Fiorenzo G. Omenetto & Michael C. McAlpine, 2012. "Graphene-based wireless bacteria detection on tooth enamel," Nature Communications, Nature, vol. 3(1), pages 1-9, January.
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