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A reversibly antigen-responsive hydrogel

Author

Listed:
  • Takashi Miyata

    (Chemical Branch, Faculty of Engineering and High Technology Research Center, Kansai University)

  • Noriko Asami

    (Chemical Branch, Faculty of Engineering and High Technology Research Center, Kansai University)

  • Tadashi Uragami

    (Chemical Branch, Faculty of Engineering and High Technology Research Center, Kansai University)

Abstract

Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedicine and the creation of ‘intelligent’ materials systems, for example as media for drug delivery, separation processes and protein immobilization. Hydrogels have been reported that respond to pH1,2,3,, temperature4,5,6,7,8,9,10,11,12,13, electric fields14,15,16, saccharides17,18,19,20,21,22,. For some biomedical applications it would be very useful to have a material whose swelling response was dictated by a specific protein. Here we report such a material, which swells reversibly in a buffer solution in response to a specific antigen. The hydrogel was prepared by grafting the antigen and corresponding antibody to the polymer network, so that binding between the two introduces crosslinks in the network. Competitive binding of the free antigen triggers a change in gel volume owing to breaking of these non-covalent crosslinks. In addition, we show that the hydrogel displays shape-memory behaviour, and that stepwise changes in antigen concentration can induce pulsatile permeation of a protein through the network.

Suggested Citation

  • Takashi Miyata & Noriko Asami & Tadashi Uragami, 1999. "A reversibly antigen-responsive hydrogel," Nature, Nature, vol. 399(6738), pages 766-769, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6738:d:10.1038_21619
    DOI: 10.1038/21619
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    Cited by:

    1. Xin Li & Rujing Sun & Jingying Pan & Zhenghan Shi & Zijian An & Chaobo Dai & Jingjiang Lv & Guang Liu & Hao Liang & Jun Liu & Yanli Lu & Fenni Zhang & Qingjun Liu, 2024. "Rapid and on-site wireless immunoassay of respiratory virus aerosols via hydrogel-modulated resonators," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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