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The great escape: a Shigella effector unlocks the septin cage

Author

Listed:
  • Ana T. López-Jiménez

    (London School of Hygiene and Tropical Medicine)

  • Gizem Özbaykal Güler

    (London School of Hygiene and Tropical Medicine)

  • Serge Mostowy

    (London School of Hygiene and Tropical Medicine)

Abstract

Shigella, an important human pathogen, can secrete effector proteins to invade host cells and evade mechanisms of cell-autonomous immunity. In a new manuscript published in Nature Communications, Xian et al. report that the Shigella kinase effector OspG promotes the ubiquitination of septin cytoskeletal proteins to evade cage entrapment.

Suggested Citation

  • Ana T. López-Jiménez & Gizem Özbaykal Güler & Serge Mostowy, 2024. "The great escape: a Shigella effector unlocks the septin cage," Nature Communications, Nature, vol. 15(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48208-1
    DOI: 10.1038/s41467-024-48208-1
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    References listed on IDEAS

    as
    1. Zilin Li & Wang Liu & Jiaqi Fu & Sen Cheng & Yue Xu & Zhiqiang Wang & Xiaofan Liu & Xuyan Shi & Yaxin Liu & Xiangbing Qi & Xiaoyun Liu & Jingjin Ding & Feng Shao, 2021. "Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11," Nature, Nature, vol. 599(7884), pages 290-295, November.
    2. Ana Teresa López-Jiménez & Serge Mostowy, 2021. "Emerging technologies and infection models in cellular microbiology," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Peng Li & Wei Jiang & Qin Yu & Wang Liu & Ping Zhou & Jun Li & Junjie Xu & Bo Xu & Fengchao Wang & Feng Shao, 2017. "Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence," Nature, Nature, vol. 551(7680), pages 378-383, November.
    Full references (including those not matched with items on IDEAS)

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