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Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

Author

Listed:
  • Peng Li

    (Peking University–Tsinghua University–National Institute of Biological Sciences Joint Graduate Program, National Institute of Biological Sciences
    National Institute of Biological Sciences)

  • Wei Jiang

    (National Institute of Biological Sciences)

  • Qin Yu

    (National Institute of Biological Sciences)

  • Wang Liu

    (National Institute of Biological Sciences)

  • Ping Zhou

    (National Institute of Biological Sciences)

  • Jun Li

    (National Institute of Biological Sciences)

  • Junjie Xu

    (National Institute of Biological Sciences)

  • Bo Xu

    (National Institute of Biological Sciences)

  • Fengchao Wang

    (National Institute of Biological Sciences)

  • Feng Shao

    (National Institute of Biological Sciences
    Collaborative Innovation Center for Cancer Medicine, National Institute of Biological Sciences)

Abstract

A Shigella flexneri type III secretion system effector targets cellular proteins for degradation via the ubiquitin/proteasome pathway, suggesting that such effectors help to overcome defences against bacterial infection.

Suggested Citation

  • Peng Li & Wei Jiang & Qin Yu & Wang Liu & Ping Zhou & Jun Li & Junjie Xu & Bo Xu & Fengchao Wang & Feng Shao, 2017. "Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence," Nature, Nature, vol. 551(7680), pages 378-383, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7680:d:10.1038_nature24467
    DOI: 10.1038/nature24467
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    Cited by:

    1. Shiyang Cao & Yang Jiao & Wei Jiang & Yarong Wu & Si Qin & Yifan Ren & Yang You & Yafang Tan & Xiao Guo & Hongyan Chen & Yuan Zhang & Gengshan Wu & Tong Wang & Yazhou Zhou & Yajun Song & Yujun Cui & F, 2022. "Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Vincenzo Torraca & Myrsini Kaforou & Jayne Watson & Gina M Duggan & Hazel Guerrero-Gutierrez & Sina Krokowski & Michael Hollinshead & Thomas B Clarke & Rafal J Mostowy & Gillian S Tomlinson & Vanessa , 2019. "Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence," PLOS Pathogens, Public Library of Science, vol. 15(12), pages 1-26, December.
    3. Ana T. López-Jiménez & Gizem Özbaykal Güler & Serge Mostowy, 2024. "The great escape: a Shigella effector unlocks the septin cage," Nature Communications, Nature, vol. 15(1), pages 1-3, December.

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