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Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting

Author

Listed:
  • Yiyan Yin

    (Beijing Normal University)

  • Xiyang Ge

    (Beijing Normal University)

  • Jin Ouyang

    (Beijing Normal University at Zhuhai)

  • Na Na

    (Beijing Normal University)

Abstract

Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and the interference from the Tumor Microenvironment (TME). Here we show a TME-activated in situ synthesis of SACs for efficient tumor-specific water-based PDT. Upon reduction by upregulated GSH in TME, C3N4-Mn SACs are obtained in TME with Mn atomically coordinated into the cavity of C3N4 nanosheets. This in situ synthesis overcomes toxicity from random distribution and catalyst release in healthy tissues. Based on the Ligand-to-Metal charge transfer (LMCT) process, C3N4-Mn SACs exhibit enhanced absorption in the red-light region. Thereby, a water-splitting process is induced by C3N4-Mn SACs under 660 nm irradiation, which initiates the O2-independent generation of highly toxic hydroxyl radical (·OH) for cancer-specific PDT. Subsequently, the ·OH-initiated lipid peroxidation process is demonstrated to devote effective cancer cell death. The in situ synthesized SACs facilitate the precise cancer-specific conversion of inert H2O to reactive ·OH, which facilitates efficient cancer therapy in female mice. This strategy achieves efficient and precise cancer therapy, not only avoiding the side effects on normal tissues but also overcoming tumor hypoxia.

Suggested Citation

  • Yiyan Yin & Xiyang Ge & Jin Ouyang & Na Na, 2024. "Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46987-1
    DOI: 10.1038/s41467-024-46987-1
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    References listed on IDEAS

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    1. P. Thangadurai & S. Ramasamy & T. K. Kundu & P. T. Manoharan, 2005. "EPR study of Mn2+ doped nanocrystalline PbF2," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 44(4), pages 447-454, April.
    2. Jiaqi Feng & Hongshuai Gao & Lirong Zheng & Zhipeng Chen & Shaojuan Zeng & Chongyang Jiang & Haifeng Dong & Licheng Liu & Suojiang Zhang & Xiangping Zhang, 2020. "A Mn-N3 single-atom catalyst embedded in graphitic carbon nitride for efficient CO2 electroreduction," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
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