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Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts

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Listed:
  • Sarah J. Aldridge

    (Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University)

  • Utkarsh Agrawal

    (University of Oxford)

  • Siobhán Murphy

    (School of Medicine, Dentistry and Biomedical Sciences, Queen’s University)

  • Tristan Millington

    (University of Edinburgh)

  • Ashley Akbari

    (Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University)

  • Fatima Almaghrabi

    (University of Edinburgh)

  • Sneha N. Anand

    (University of Oxford)

  • Stuart Bedston

    (Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University)

  • Rosalind Goudie

    (University of Oxford)

  • Rowena Griffiths

    (Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University)

  • Mark Joy

    (University of Oxford)

  • Emily Lowthian

    (School of Social Sciences, Swansea University)

  • Simon Lusignan

    (University of Oxford)

  • Lynsey Patterson

    (School of Medicine, Dentistry and Biomedical Sciences, Queen’s University
    Public Health Agency)

  • Chris Robertson

    (Strathclyde University, Glasgow, UK and Public Health Scotland)

  • Igor Rudan

    (Usher Institute, the University of Edinburgh)

  • Declan T. Bradley

    (School of Medicine, Dentistry and Biomedical Sciences, Queen’s University
    Public Health Agency)

  • Ronan A. Lyons

    (Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University)

  • Aziz Sheikh

    (University of Oxford)

  • Rhiannon K. Owen

    (Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University)

Abstract

SARS-CoV-2 infection in children and young people (CYP) can lead to life-threatening COVID-19, transmission within households and schools, and the development of long COVID. Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5–17 years across all UK nations between 4th August 2021 and 31st May 2022. We constructed national cohorts and undertook multi-state modelling and meta-analysis to identify associations between demographic variables and vaccine uptake. We found that uptake of the first COVID-19 vaccine among CYP was low across all four nations compared to other age groups and diminished with subsequent doses. Age and vaccination status of adults living in the same household were identified as important risk factors associated with vaccine uptake in CYP. For example, 5–11 year-olds were less likely to receive their first vaccine compared to 16–17 year-olds (adjusted Hazard Ratio [aHR]: 0.10 (95%CI: 0.06–0.19)), and CYP in unvaccinated households were less likely to receive their first vaccine compared to CYP in partially vaccinated households (aHR: 0.19, 95%CI 0.13–0.29).

Suggested Citation

  • Sarah J. Aldridge & Utkarsh Agrawal & Siobhán Murphy & Tristan Millington & Ashley Akbari & Fatima Almaghrabi & Sneha N. Anand & Stuart Bedston & Rosalind Goudie & Rowena Griffiths & Mark Joy & Emily , 2024. "Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46451-0
    DOI: 10.1038/s41467-024-46451-0
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