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Control of feeding by a bottom-up midbrain-subthalamic pathway

Author

Listed:
  • Fernando M. C. V. Reis

    (University of California, Los Angeles)

  • Sandra Maesta-Pereira

    (University of California, Los Angeles)

  • Matthias Ollivier

    (University of California, Los Angeles)

  • Peter J. Schuette

    (University of California, Los Angeles)

  • Ekayana Sethi

    (University of California, Los Angeles)

  • Blake A. Miranda

    (University of California, Los Angeles)

  • Emily Iniguez

    (University of California, Los Angeles)

  • Meghmik Chakerian

    (University of California, Los Angeles)

  • Eric Vaughn

    (Harvard University)

  • Megha Sehgal

    (University of California, Los Angeles)

  • Darren C. T. Nguyen

    (University of California, Los Angeles)

  • Faith T. H. Yuan

    (University of California, Los Angeles)

  • Anita Torossian

    (University of California, Los Angeles)

  • Juliane M. Ikebara

    (Universidade Federal do ABC)

  • Alexandre H. Kihara

    (Universidade Federal do ABC)

  • Alcino J. Silva

    (University of California, Los Angeles
    University of California, Los Angeles
    University of California, Los Angeles)

  • Jonathan C. Kao

    (University of California, Los Angeles)

  • Baljit S. Khakh

    (University of California, Los Angeles)

  • Avishek Adhikari

    (University of California, Los Angeles)

Abstract

Investigative exploration and foraging leading to food consumption have vital importance, but are not well-understood. Since GABAergic inputs to the lateral and ventrolateral periaqueductal gray (l/vlPAG) control such behaviors, we dissected the role of vgat-expressing GABAergic l/vlPAG cells in exploration, foraging and hunting. Here, we show that in mice vgat l/vlPAG cells encode approach to food and consumption of both live prey and non-prey foods. The activity of these cells is necessary and sufficient for inducing food-seeking leading to subsequent consumption. Activation of vgat l/vlPAG cells produces exploratory foraging and compulsive eating without altering defensive behaviors. Moreover, l/vlPAG vgat cells are bidirectionally interconnected to several feeding, exploration and investigation nodes, including the zona incerta. Remarkably, the vgat l/vlPAG projection to the zona incerta bidirectionally controls approach towards food leading to consumption. These data indicate the PAG is not only a final downstream target of top-down exploration and foraging-related inputs, but that it also influences these behaviors through a bottom-up pathway.

Suggested Citation

  • Fernando M. C. V. Reis & Sandra Maesta-Pereira & Matthias Ollivier & Peter J. Schuette & Ekayana Sethi & Blake A. Miranda & Emily Iniguez & Meghmik Chakerian & Eric Vaughn & Megha Sehgal & Darren C. T, 2024. "Control of feeding by a bottom-up midbrain-subthalamic pathway," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46430-5
    DOI: 10.1038/s41467-024-46430-5
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    References listed on IDEAS

    as
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