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Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications

Author

Listed:
  • Yuxuan Sun

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Wang Zhang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Junnan Gu

    (Huazhong University of Science and Technology)

  • Liangyu Xia

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Yinghao Cao

    (Huazhong University of Science and Technology)

  • Xinhui Zhu

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Hao Wen

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Shaowei Ouyang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Ruiqi Liu

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Jialong Li

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Zhenxing Jiang

    (Huazhong University of Science and Technology)

  • Denglong Cheng

    (Huazhong University of Science and Technology)

  • Yiliang Lv

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Xiaotao Han

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Wu Qiu

    (Huazhong University of Science and Technology)

  • Kailin Cai

    (Huazhong University of Science and Technology)

  • Enmin Song

    (Huazhong University of Science and Technology)

  • Quanliang Cao

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Liang Li

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the narrow spatial structure of the capsule and complex gastrointestinal tract environment cause many open-ended problems, such as poor active motion and limited medical functions. In this work, we describe the development of small-scale magnetically driven capsules with a distinct magnetic soft valve made of dual-layer ferromagnetic soft composite films. A core technological advancement achieved is the flexible opening and closing of the magnetic soft valve by using the competitive interactions between magnetic gradient force and magnetic torque, laying the foundation for the functional integration of both drug release and sampling. Meanwhile, we propose a magnetic actuation strategy based on multi-frequency response control and demonstrate that it can achieve effective decoupled regulation of the capsule’s global motion and local responses. Finally, through a comprehensive approach encompassing ideal models, animal ex vivo models, and in vivo assessment, we demonstrate the versatility of the developed magnetic capsules and their multiple potential applications in the biomedical field, such as targeted drug delivery and sampling, selective dual-drug release, and light/thermal-assisted therapy.

Suggested Citation

  • Yuxuan Sun & Wang Zhang & Junnan Gu & Liangyu Xia & Yinghao Cao & Xinhui Zhu & Hao Wen & Shaowei Ouyang & Ruiqi Liu & Jialong Li & Zhenxing Jiang & Denglong Cheng & Yiliang Lv & Xiaotao Han & Wu Qiu &, 2024. "Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46046-9
    DOI: 10.1038/s41467-024-46046-9
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    References listed on IDEAS

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    1. Cheng Zhou & Youzhou Yang & Jiaxin Wang & Qingyang Wu & Zhuozhi Gu & Yuting Zhou & Xurui Liu & Yueying Yang & Hanchuan Tang & Qing Ling & Liu Wang & Jianfeng Zang, 2021. "Ferromagnetic soft catheter robots for minimally invasive bioprinting," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Qiji Ze & Shuai Wu & Jize Dai & Sophie Leanza & Gentaro Ikeda & Phillip C. Yang & Gianluca Iaccarino & Ruike Renee Zhao, 2022. "Spinning-enabled wireless amphibious origami millirobot," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Yoonho Kim & Hyunwoo Yuk & Ruike Zhao & Shawn A. Chester & Xuanhe Zhao, 2018. "Printing ferromagnetic domains for untethered fast-transforming soft materials," Nature, Nature, vol. 558(7709), pages 274-279, June.
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    Cited by:

    1. Qing Cao & Runyi Deng & Yue Pan & Ruijie Liu & Yicheng Chen & Guofang Gong & Jun Zou & Huayong Yang & Dong Han, 2024. "Robotic wireless capsule endoscopy: recent advances and upcoming technologies," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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