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Ferromagnetic soft catheter robots for minimally invasive bioprinting

Author

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  • Cheng Zhou

    (Huazhong University of Science and Technology)

  • Youzhou Yang

    (Huazhong University of Science and Technology)

  • Jiaxin Wang

    (Huazhong University of Science and Technology)

  • Qingyang Wu

    (Huazhong University of Science and Technology)

  • Zhuozhi Gu

    (Huazhong University of Science and Technology)

  • Yuting Zhou

    (Jilin University)

  • Xurui Liu

    (Huazhong University of Science and Technology)

  • Yueying Yang

    (Huazhong University of Science and Technology)

  • Hanchuan Tang

    (Huazhong University of Science and Technology)

  • Qing Ling

    (Huazhong University of Science and Technology)

  • Liu Wang

    (University of Science and Technology of China)

  • Jianfeng Zang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

In vivo bioprinting has recently emerged as a direct fabrication technique to create artificial tissues and medical devices on target sites within the body, enabling advanced clinical strategies. However, existing in vivo bioprinting methods are often limited to applications near the skin or require open surgery for printing on internal organs. Here, we report a ferromagnetic soft catheter robot (FSCR) system capable of in situ computer-controlled bioprinting in a minimally invasive manner based on magnetic actuation. The FSCR is designed by dispersing ferromagnetic particles in a fiber-reinforced polymer matrix. This design results in stable ink extrusion and allows for printing various materials with different rheological properties and functionalities. A superimposed magnetic field drives the FSCR to achieve digitally controlled printing with high accuracy. We demonstrate printing multiple patterns on planar surfaces, and considering the non-planar surface of natural organs, we then develop an in situ printing strategy for curved surfaces and demonstrate minimally invasive in vivo bioprinting of hydrogels in a rat model. Our catheter robot will permit intelligent and minimally invasive bio-fabrication.

Suggested Citation

  • Cheng Zhou & Youzhou Yang & Jiaxin Wang & Qingyang Wu & Zhuozhi Gu & Yuting Zhou & Xurui Liu & Yueying Yang & Hanchuan Tang & Qing Ling & Liu Wang & Jianfeng Zang, 2021. "Ferromagnetic soft catheter robots for minimally invasive bioprinting," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25386-w
    DOI: 10.1038/s41467-021-25386-w
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    Cited by:

    1. Liyang Mao & Peng Yang & Chenyao Tian & Xingjian Shen & Feihao Wang & Hao Zhang & Xianghe Meng & Hui Xie, 2024. "Magnetic steering continuum robot for transluminal procedures with programmable shape and functionalities," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ziheng Chen & Yibin Wang & Hui Chen & Junhui Law & Huayan Pu & Shaorong Xie & Feng Duan & Yu Sun & Na Liu & Jiangfan Yu, 2024. "A magnetic multi-layer soft robot for on-demand targeted adhesion," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Yuxuan Sun & Liu Wang & Yangyang Ni & Huajian Zhang & Xiang Cui & Jiahao Li & Yinbo Zhu & Ji Liu & Shiwu Zhang & Yong Chen & Mujun Li, 2023. "3D printing of thermosets with diverse rheological and functional applicabilities," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Shengzhu Yi & Liu Wang & Zhipeng Chen & Jian Wang & Xingyi Song & Pengfei Liu & Yuanxi Zhang & Qingqing Luo & Lelun Peng & Zhigang Wu & Chuan Fei Guo & Lelun Jiang, 2022. "High-throughput fabrication of soft magneto-origami machines," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Yuxuan Sun & Wang Zhang & Junnan Gu & Liangyu Xia & Yinghao Cao & Xinhui Zhu & Hao Wen & Shaowei Ouyang & Ruiqi Liu & Jialong Li & Zhenxing Jiang & Denglong Cheng & Yiliang Lv & Xiaotao Han & Wu Qiu &, 2024. "Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Yuanxi Zhang & Chengfeng Pan & Pengfei Liu & Lelun Peng & Zhouming Liu & Yuanyuan Li & Qingyuan Wang & Tong Wu & Zhe Li & Carmel Majidi & Lelun Jiang, 2023. "Coaxially printed magnetic mechanical electrical hybrid structures with actuation and sensing functionalities," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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