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Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Author

Listed:
  • Inge Seim

    (Brigham and Women’s Hospital, Harvard Medical School
    Ewha Womans University)

  • Xiaodong Fang

    (BGI-Shenzhen
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen)

  • Zhiqiang Xiong

    (BGI-Shenzhen)

  • Alexey V. Lobanov

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Zhiyong Huang

    (BGI-Shenzhen)

  • Siming Ma

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Yue Feng

    (BGI-Shenzhen)

  • Anton A. Turanov

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Yabing Zhu

    (BGI-Shenzhen)

  • Tobias L. Lenz

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Maxim V. Gerashchenko

    (Brigham and Women’s Hospital, Harvard Medical School
    University of Nebraska)

  • Dingding Fan

    (BGI-Shenzhen)

  • Sun Hee Yim

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xiaoming Yao

    (BGI-Shenzhen)

  • Daniel Jordan

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Yingqi Xiong

    (BGI-Shenzhen)

  • Yong Ma

    (BGI-Shenzhen)

  • Andrey N. Lyapunov

    (Kirov State Center for Distance Education of Children)

  • Guanxing Chen

    (BGI-Shenzhen)

  • Oksana I. Kulakova

    (Institute of Biology, Komi Science Center, Russian Academy of Sciences)

  • Yudong Sun

    (BGI-Shenzhen)

  • Sang-Goo Lee

    (Ewha Womans University)

  • Roderick T. Bronson

    (Rodent Histopathology Laboratory, Harvard Medical School)

  • Alexey A. Moskalev

    (Institute of Biology, Komi Science Center, Russian Academy of Sciences
    Syktyvkar State University
    Moscow Institute of Physics and Technology)

  • Shamil R. Sunyaev

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Guojie Zhang

    (BGI-Shenzhen)

  • Anders Krogh

    (Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen)

  • Jun Wang

    (BGI-Shenzhen
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
    University of Copenhagen)

  • Vadim N. Gladyshev

    (Brigham and Women’s Hospital, Harvard Medical School
    Ewha Womans University)

Abstract

Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4–8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt’s bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt’s bat.

Suggested Citation

  • Inge Seim & Xiaodong Fang & Zhiqiang Xiong & Alexey V. Lobanov & Zhiyong Huang & Siming Ma & Yue Feng & Anton A. Turanov & Yabing Zhu & Tobias L. Lenz & Maxim V. Gerashchenko & Dingding Fan & Sun Hee , 2013. "Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii," Nature Communications, Nature, vol. 4(1), pages 1-8, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3212
    DOI: 10.1038/ncomms3212
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    Cited by:

    1. Rong Hua & Yuan-Shuo Ma & Lu Yang & Jun-Jun Hao & Qin-Yang Hua & Lu-Ye Shi & Xiao-Qing Yao & Hao-Yu Zhi & Zhen Liu, 2024. "Experimental evidence for cancer resistance in a bat species," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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