IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45282-3.html
   My bibliography  Save this article

Brain asymmetries from mid- to late life and hemispheric brain age

Author

Listed:
  • Max Korbmacher

    (Western Norway University of Applied Sciences
    University of Oslo and Oslo University Hospital
    Mohn Medical Imaging and Visualization Centre (MMIV))

  • Dennis Meer

    (University of Oslo and Oslo University Hospital
    Maastricht University)

  • Dani Beck

    (University of Oslo and Oslo University Hospital
    Diakonhjemmet Hospital
    University of Oslo)

  • Ann-Marie G. de Lange

    (University of Oslo and Oslo University Hospital
    Lausanne University Hospital (CHUV) and University of Lausanne
    University of Oxford)

  • Eli Eikefjord

    (Western Norway University of Applied Sciences
    Mohn Medical Imaging and Visualization Centre (MMIV))

  • Arvid Lundervold

    (Mohn Medical Imaging and Visualization Centre (MMIV)
    University of Bergen)

  • Ole A. Andreassen

    (University of Oslo and Oslo University Hospital
    University of Oslo)

  • Lars T. Westlye

    (University of Oslo and Oslo University Hospital
    University of Oslo
    University of Oslo)

  • Ivan I. Maximov

    (Western Norway University of Applied Sciences
    University of Oslo and Oslo University Hospital)

Abstract

The human brain demonstrates structural and functional asymmetries which have implications for ageing and mental and neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from structural and diffusion MRI data in N=48,040 UK Biobank participants to evaluate age-related differences in brain asymmetry. Most regional grey and white matter metrics presented asymmetry, which were higher later in life. Informed by these results, we conducted hemispheric brain age (HBA) predictions from left/right multimodal MRI metrics. HBA was concordant to conventional brain age predictions, using metrics from both hemispheres, but offers a supplemental general marker of brain asymmetry when setting left/right HBA into relationship with each other. In contrast to WM brain asymmetries, left/right discrepancies in HBA are lower at higher ages. Our findings outline various sex-specific differences, particularly important for brain age estimates, and the value of further investigating the role of brain asymmetries in brain ageing and disease development.

Suggested Citation

  • Max Korbmacher & Dennis Meer & Dani Beck & Ann-Marie G. de Lange & Eli Eikefjord & Arvid Lundervold & Ole A. Andreassen & Lars T. Westlye & Ivan I. Maximov, 2024. "Brain asymmetries from mid- to late life and hemispheric brain age," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45282-3
    DOI: 10.1038/s41467-024-45282-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45282-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45282-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Vyacheslav R. Karolis & Maurizio Corbetta & Michel Thiebaut de Schotten, 2019. "The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    2. Karin Saltoun & Ralph Adolphs & Lynn K. Paul & Vaibhav Sharma & Joern Diedrichsen & B. T. Thomas Yeo & Danilo Bzdok, 2023. "Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles," Nature Human Behaviour, Nature, vol. 7(2), pages 251-268, February.
    3. Tabea Schoeler & Doug Speed & Eleonora Porcu & Nicola Pirastu & Jean-Baptiste Pingault & Zoltán Kutalik, 2023. "Participation bias in the UK Biobank distorts genetic associations and downstream analyses," Nature Human Behaviour, Nature, vol. 7(7), pages 1216-1227, July.
    4. James M. Roe & Didac Vidal-Piñeiro & Øystein Sørensen & Andreas M. Brandmaier & Sandra Düzel & Hector A. Gonzalez & Rogier A. Kievit & Ethan Knights & Simone Kühn & Ulman Lindenberger & Athanasia M. M, 2021. "Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Zhiqiang Sha & Dick Schijven & Amaia Carrion-Castillo & Marc Joliot & Bernard Mazoyer & Simon E. Fisher & Fabrice Crivello & Clyde Francks, 2021. "The genetic architecture of structural left–right asymmetry of the human brain," Nature Human Behaviour, Nature, vol. 5(9), pages 1226-1239, September.
    2. Liu Yang & Ya-Nan Ou & Bang-Sheng Wu & Wei-Shi Liu & Yue-Ting Deng & Xiao-Yu He & Yi-Lin Chen & Jujiao Kang & Chen-Jie Fei & Ying Zhu & Lan Tan & Qiang Dong & Jianfeng Feng & Wei Cheng & Jin-Tai Yu, 2024. "Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Loren Koçillari & Silvia Cattelan & Maria Berica Rasotto & Flavio Seno & Amos Maritan & Andrea Pilastro, 2024. "Tetrapod sperm length evolution in relation to body mass is shaped by multiple trade-offs," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Mingyang Li & Xixi Dang & Yiwei Chen & Zhifan Chen & Xinyi Xu & Zhiyong Zhao & Dan Wu, 2024. "Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Loïc Labache & Tian Ge & B. T. Thomas Yeo & Avram J. Holmes, 2023. "Language network lateralization is reflected throughout the macroscale functional organization of cortex," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45282-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.