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Brain asymmetries from mid- to late life and hemispheric brain age

Author

Listed:
  • Max Korbmacher

    (Western Norway University of Applied Sciences
    University of Oslo and Oslo University Hospital
    Mohn Medical Imaging and Visualization Centre (MMIV))

  • Dennis Meer

    (University of Oslo and Oslo University Hospital
    Maastricht University)

  • Dani Beck

    (University of Oslo and Oslo University Hospital
    Diakonhjemmet Hospital
    University of Oslo)

  • Ann-Marie G. de Lange

    (University of Oslo and Oslo University Hospital
    Lausanne University Hospital (CHUV) and University of Lausanne
    University of Oxford)

  • Eli Eikefjord

    (Western Norway University of Applied Sciences
    Mohn Medical Imaging and Visualization Centre (MMIV))

  • Arvid Lundervold

    (Mohn Medical Imaging and Visualization Centre (MMIV)
    University of Bergen)

  • Ole A. Andreassen

    (University of Oslo and Oslo University Hospital
    University of Oslo)

  • Lars T. Westlye

    (University of Oslo and Oslo University Hospital
    University of Oslo
    University of Oslo)

  • Ivan I. Maximov

    (Western Norway University of Applied Sciences
    University of Oslo and Oslo University Hospital)

Abstract

The human brain demonstrates structural and functional asymmetries which have implications for ageing and mental and neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from structural and diffusion MRI data in N=48,040 UK Biobank participants to evaluate age-related differences in brain asymmetry. Most regional grey and white matter metrics presented asymmetry, which were higher later in life. Informed by these results, we conducted hemispheric brain age (HBA) predictions from left/right multimodal MRI metrics. HBA was concordant to conventional brain age predictions, using metrics from both hemispheres, but offers a supplemental general marker of brain asymmetry when setting left/right HBA into relationship with each other. In contrast to WM brain asymmetries, left/right discrepancies in HBA are lower at higher ages. Our findings outline various sex-specific differences, particularly important for brain age estimates, and the value of further investigating the role of brain asymmetries in brain ageing and disease development.

Suggested Citation

  • Max Korbmacher & Dennis Meer & Dani Beck & Ann-Marie G. de Lange & Eli Eikefjord & Arvid Lundervold & Ole A. Andreassen & Lars T. Westlye & Ivan I. Maximov, 2024. "Brain asymmetries from mid- to late life and hemispheric brain age," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45282-3
    DOI: 10.1038/s41467-024-45282-3
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    References listed on IDEAS

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    1. James M. Roe & Didac Vidal-Piñeiro & Øystein Sørensen & Andreas M. Brandmaier & Sandra Düzel & Hector A. Gonzalez & Rogier A. Kievit & Ethan Knights & Simone Kühn & Ulman Lindenberger & Athanasia M. M, 2021. "Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
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    3. Karin Saltoun & Ralph Adolphs & Lynn K. Paul & Vaibhav Sharma & Joern Diedrichsen & B. T. Thomas Yeo & Danilo Bzdok, 2023. "Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles," Nature Human Behaviour, Nature, vol. 7(2), pages 251-268, February.
    4. Tabea Schoeler & Doug Speed & Eleonora Porcu & Nicola Pirastu & Jean-Baptiste Pingault & Zoltán Kutalik, 2023. "Participation bias in the UK Biobank distorts genetic associations and downstream analyses," Nature Human Behaviour, Nature, vol. 7(7), pages 1216-1227, July.
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