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Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles

Author

Listed:
  • Karin Saltoun

    (McGill University
    Mila - Quebec Artificial Intelligence Institute
    McGill University
    McGill University)

  • Ralph Adolphs

    (California Institute of Technology
    California Institute of Technology)

  • Lynn K. Paul

    (California Institute of Technology
    International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5)
    Travis Research Institute)

  • Vaibhav Sharma

    (McGill University
    Mila - Quebec Artificial Intelligence Institute)

  • Joern Diedrichsen

    (Western University
    Western University
    Western University)

  • B. T. Thomas Yeo

    (National University of Singapore
    Yong Loo Lin School of Medicine
    National University of Singapore)

  • Danilo Bzdok

    (McGill University
    Mila - Quebec Artificial Intelligence Institute)

Abstract

Broca reported ~150 years ago that particular lesions of the left hemisphere impair speech. Since then, other brain regions have been reported to show lateralized structure and function. Yet, studies of brain asymmetry have limited their focus to pairwise comparisons between homologous regions. Here, we characterized separable whole-brain asymmetry patterns in grey and white matter structure from n = 37,441 UK Biobank participants. By pooling information on left–right shifts underlying whole-brain structure, we deconvolved signatures of brain asymmetry that are spatially distributed rather than locally constrained. Classically asymmetric regions turned out to belong to more than one asymmetry pattern. Instead of a single dominant signature, we discovered complementary asymmetry patterns that contributed similarly to whole-brain asymmetry at the population level. These asymmetry patterns were associated with unique collections of phenotypes, ranging from early lifestyle factors to demographic status to mental health indicators.

Suggested Citation

  • Karin Saltoun & Ralph Adolphs & Lynn K. Paul & Vaibhav Sharma & Joern Diedrichsen & B. T. Thomas Yeo & Danilo Bzdok, 2023. "Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles," Nature Human Behaviour, Nature, vol. 7(2), pages 251-268, February.
    • Handle: RePEc:nat:nathum:v:7:y:2023:i:2:d:10.1038_s41562-022-01461-0
    DOI: 10.1038/s41562-022-01461-0
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    Cited by:

    1. Max Korbmacher & Dennis Meer & Dani Beck & Ann-Marie G. de Lange & Eli Eikefjord & Arvid Lundervold & Ole A. Andreassen & Lars T. Westlye & Ivan I. Maximov, 2024. "Brain asymmetries from mid- to late life and hemispheric brain age," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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