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The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain

Author

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  • Vyacheslav R. Karolis

    (Sorbonne Universities
    Institut du Cerveau et de la Moelle épinière (ICM))

  • Maurizio Corbetta

    (University of Padova
    University of Padova
    Fondazione Biomedica
    Washington University)

  • Michel Thiebaut de Schotten

    (Sorbonne Universities
    Institut du Cerveau et de la Moelle épinière (ICM)
    CEA University of Bordeaux)

Abstract

Functional lateralisation is a fundamental principle of the human brain. However, a comprehensive taxonomy of functional lateralisation and its organisation in the brain is missing. Here, we report the first complete map of functional hemispheric asymmetries in the human brain, reveal its low dimensional structure, and its relationship with structural inter-hemispheric connectivity. Our results suggest that the lateralisation of brain functions is distributed along four functional axes: symbolic communication, perception/action, emotion, and decision-making. The similarity between this finding and recent work on neurological symptoms give rise to new hypotheses on the mechanisms that support brain recovery after a brain lesion. We also report that cortical regions showing asymmetries in task-evoked activity have reduced connections with the opposite hemisphere. This latter result suggests that during evolution, brain size expansion led to functional lateralisation to avoid excessive conduction delays between the hemispheres.

Suggested Citation

  • Vyacheslav R. Karolis & Maurizio Corbetta & Michel Thiebaut de Schotten, 2019. "The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09344-1
    DOI: 10.1038/s41467-019-09344-1
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    Cited by:

    1. Max Korbmacher & Dennis Meer & Dani Beck & Ann-Marie G. de Lange & Eli Eikefjord & Arvid Lundervold & Ole A. Andreassen & Lars T. Westlye & Ivan I. Maximov, 2024. "Brain asymmetries from mid- to late life and hemispheric brain age," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Loren Koçillari & Silvia Cattelan & Maria Berica Rasotto & Flavio Seno & Amos Maritan & Andrea Pilastro, 2024. "Tetrapod sperm length evolution in relation to body mass is shaped by multiple trade-offs," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Loïc Labache & Tian Ge & B. T. Thomas Yeo & Avram J. Holmes, 2023. "Language network lateralization is reflected throughout the macroscale functional organization of cortex," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Zhiqiang Sha & Dick Schijven & Amaia Carrion-Castillo & Marc Joliot & Bernard Mazoyer & Simon E. Fisher & Fabrice Crivello & Clyde Francks, 2021. "The genetic architecture of structural left–right asymmetry of the human brain," Nature Human Behaviour, Nature, vol. 5(9), pages 1226-1239, September.
    5. Valentina Pacella & Victor Nozais & Lia Talozzi & Majd Abdallah & Demian Wassermann & Stephanie J. Forkel & Michel Thiebaut de Schotten, 2024. "The morphospace of the brain-cognition organisation," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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