IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45260-9.html
   My bibliography  Save this article

Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

Author

Listed:
  • Sebastian Brandhorst

    (University of Southern California)

  • Morgan E. Levine

    (Yale School of Medicine)

  • Min Wei

    (University of Southern California)

  • Mahshid Shelehchi

    (University of Southern California)

  • Todd E. Morgan

    (University of Southern California)

  • Krishna S. Nayak

    (Viterbi School of Engineering, University of Southern California)

  • Tanya Dorff

    (Keck School of Medicine, University of Southern California)

  • Kurt Hong

    (Keck School of Medicine of USC)

  • Eileen M. Crimmins

    (University of Southern California
    University of California Los Angeles and University of Southern California)

  • Pinchas Cohen

    (University of Southern California)

  • Valter D. Longo

    (University of Southern California
    Italian Foundation for Cancer Research Institute of Molecular Oncology)

Abstract

In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss. Nearly identical findings resulted from a second clinical study (NCT04150159). Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.

Suggested Citation

  • Sebastian Brandhorst & Morgan E. Levine & Min Wei & Mahshid Shelehchi & Todd E. Morgan & Krishna S. Nayak & Tanya Dorff & Kurt Hong & Eileen M. Crimmins & Pinchas Cohen & Valter D. Longo, 2024. "Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45260-9
    DOI: 10.1038/s41467-024-45260-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45260-9
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-45260-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ricki J. Colman & T. Mark Beasley & Joseph W. Kemnitz & Sterling C. Johnson & Richard Weindruch & Rozalyn M. Anderson, 2014. "Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys," Nature Communications, Nature, vol. 5(1), pages 1-5, May.
    2. Julie A. Mattison & Ricki J. Colman & T. Mark Beasley & David B. Allison & Joseph W. Kemnitz & George S. Roth & Donald K. Ingram & Richard Weindruch & Rafael de Cabo & Rozalyn M. Anderson, 2017. "Caloric restriction improves health and survival of rhesus monkeys," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Elite Possik & Laura-Lee Klein & Perla Sanjab & Ruyuan Zhu & Laurence Côté & Ying Bai & Dongwei Zhang & Howard Sun & Anfal Al-Mass & Abel Oppong & Rasheed Ahmad & Alex Parker & S.R. Murthy Madiraju & , 2023. "Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. John P. Phelan, 2018. "Generating insights into human aging from experimental evolution using bats (or other “slow” life history species)," Journal of Bioeconomics, Springer, vol. 20(1), pages 165-173, April.
    3. Hagai Yanai & Bongsoo Park & Hyunwook Koh & Hyo Jung Jang & Kelli L. Vaughan & Mayuri Tanaka-Yano & Miguel Aon & Madison Blanton & Ilhem Messaoudi & Alberto Diaz-Ruiz & Julie A. Mattison & Isabel Beer, 2024. "Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Laura C. D. Pomatto-Watson & Monica Bodogai & Oye Bosompra & Jonathan Kato & Sarah Wong & Melissa Carpenter & Eleonora Duregon & Dolly Chowdhury & Priya Krishna & Sandy Ng & Emeline Ragonnaud & Robert, 2021. "Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45260-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.