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Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

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  • Sebastian Brandhorst

    (University of Southern California)

  • Morgan E. Levine

    (Yale School of Medicine)

  • Min Wei

    (University of Southern California)

  • Mahshid Shelehchi

    (University of Southern California)

  • Todd E. Morgan

    (University of Southern California)

  • Krishna S. Nayak

    (Viterbi School of Engineering, University of Southern California)

  • Tanya Dorff

    (Keck School of Medicine, University of Southern California)

  • Kurt Hong

    (Keck School of Medicine of USC)

  • Eileen M. Crimmins

    (University of Southern California
    University of California Los Angeles and University of Southern California)

  • Pinchas Cohen

    (University of Southern California)

  • Valter D. Longo

    (University of Southern California
    Italian Foundation for Cancer Research Institute of Molecular Oncology)

Abstract

In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss. Nearly identical findings resulted from a second clinical study (NCT04150159). Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.

Suggested Citation

  • Sebastian Brandhorst & Morgan E. Levine & Min Wei & Mahshid Shelehchi & Todd E. Morgan & Krishna S. Nayak & Tanya Dorff & Kurt Hong & Eileen M. Crimmins & Pinchas Cohen & Valter D. Longo, 2024. "Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45260-9
    DOI: 10.1038/s41467-024-45260-9
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    References listed on IDEAS

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    1. Julie A. Mattison & Ricki J. Colman & T. Mark Beasley & David B. Allison & Joseph W. Kemnitz & George S. Roth & Donald K. Ingram & Richard Weindruch & Rafael de Cabo & Rozalyn M. Anderson, 2017. "Caloric restriction improves health and survival of rhesus monkeys," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    2. Ricki J. Colman & T. Mark Beasley & Joseph W. Kemnitz & Sterling C. Johnson & Richard Weindruch & Rozalyn M. Anderson, 2014. "Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys," Nature Communications, Nature, vol. 5(1), pages 1-5, May.
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