IDEAS home Printed from https://ideas.repec.org/a/kap/jbioec/v20y2018i1d10.1007_s10818-017-9262-y.html
   My bibliography  Save this article

Generating insights into human aging from experimental evolution using bats (or other “slow” life history species)

Author

Listed:
  • John P. Phelan

    (UCLA)

Abstract

Our understanding of the complex process of aging has benefitted greatly from experimental evolution. The traditional animal models for human aging, however, are all characterized by “fast” life-histories, with rapid development, short lifespan and intensive, early investment in reproduction. This is in sharp contrast to the characteristics of the human life history and so may lead to inappropriate extrapolations about processes important in human aging. In response to these challenges and for better understanding and intervening in processes fundamental to aging in humans, I propose programs of experimental evolution for both delayed reproduction and for accelerated development in a bat species with a significantly slower life history than traditional animal models for human aging.

Suggested Citation

  • John P. Phelan, 2018. "Generating insights into human aging from experimental evolution using bats (or other “slow” life history species)," Journal of Bioeconomics, Springer, vol. 20(1), pages 165-173, April.
  • Handle: RePEc:kap:jbioec:v:20:y:2018:i:1:d:10.1007_s10818-017-9262-y
    DOI: 10.1007/s10818-017-9262-y
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s10818-017-9262-y
    File Function: Abstract
    Download Restriction: Access to full text is restricted to subscribers.

    File URL: https://libkey.io/10.1007/s10818-017-9262-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Julie A. Mattison & Ricki J. Colman & T. Mark Beasley & David B. Allison & Joseph W. Kemnitz & George S. Roth & Donald K. Ingram & Richard Weindruch & Rafael de Cabo & Rozalyn M. Anderson, 2017. "Caloric restriction improves health and survival of rhesus monkeys," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    2. Terence C. Burnham & Aimee Dunlap & David W. Stephens, 2015. "Experimental Evolution and Economics," SAGE Open, , vol. 5(4), pages 21582440156, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Elite Possik & Laura-Lee Klein & Perla Sanjab & Ruyuan Zhu & Laurence Côté & Ying Bai & Dongwei Zhang & Howard Sun & Anfal Al-Mass & Abel Oppong & Rasheed Ahmad & Alex Parker & S.R. Murthy Madiraju & , 2023. "Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Andrew W. Lo & H. Allen Orr & Ruixun Zhang, 2018. "The growth of relative wealth and the Kelly criterion," Journal of Bioeconomics, Springer, vol. 20(1), pages 49-67, April.
    3. H. Allen Orr, 2018. "Evolution, finance, and the population genetics of relative wealth," Journal of Bioeconomics, Springer, vol. 20(1), pages 29-48, April.
    4. Maria Pia Paganelli, 2018. "Adam Smith on the future of experimental evolution and economics," Journal of Bioeconomics, Springer, vol. 20(1), pages 23-28, April.
    5. Terence C. Burnham & John P. Phelan, 2018. "Fair is foul, and foul is fair: experimental evolutionary studies of mismatch," Journal of Bioeconomics, Springer, vol. 20(1), pages 153-157, April.
    6. Roberto Cazzolla Gatti & Roger Koppl & Brian D. Fath & Stuart Kauffman & Wim Hordijk & Robert E. Ulanowicz, 2020. "On the emergence of ecological and economic niches," Journal of Bioeconomics, Springer, vol. 22(2), pages 99-127, July.
    7. Paul J. Zak, 2018. "The evolutionary origins of cooperation and trade," Journal of Bioeconomics, Springer, vol. 20(1), pages 179-181, April.
    8. Richard E. Lenski & Terence C. Burnham, 2018. "Experimental evolution of bacteria across 60,000 generations, and what it might mean for economics and human decision-making," Journal of Bioeconomics, Springer, vol. 20(1), pages 107-124, April.
    9. Laura C. D. Pomatto-Watson & Monica Bodogai & Oye Bosompra & Jonathan Kato & Sarah Wong & Melissa Carpenter & Eleonora Duregon & Dolly Chowdhury & Priya Krishna & Sandy Ng & Emeline Ragonnaud & Robert, 2021. "Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    10. Sebastian Brandhorst & Morgan E. Levine & Min Wei & Mahshid Shelehchi & Todd E. Morgan & Krishna S. Nayak & Tanya Dorff & Kurt Hong & Eileen M. Crimmins & Pinchas Cohen & Valter D. Longo, 2024. "Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    11. Hagai Yanai & Bongsoo Park & Hyunwook Koh & Hyo Jung Jang & Kelli L. Vaughan & Mayuri Tanaka-Yano & Miguel Aon & Madison Blanton & Ilhem Messaoudi & Alberto Diaz-Ruiz & Julie A. Mattison & Isabel Beer, 2024. "Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    12. Mellissa Marcus & Terence C. Burnham & David W. Stephens & Aimee S. Dunlap, 2018. "Experimental evolution of color preference for oviposition in Drosophila melanogaster," Journal of Bioeconomics, Springer, vol. 20(1), pages 125-140, April.
    13. Terence C. Burnham, 2016. "Economics and evolutionary mismatch: humans in novel settings do not maximize," Journal of Bioeconomics, Springer, vol. 18(3), pages 195-209, October.
    14. J. Jeffrey Morris & Eric Schniter, 2018. "Black Queen markets: commensalism, dependency, and the evolution of cooperative specialization in human society," Journal of Bioeconomics, Springer, vol. 20(1), pages 69-105, April.
    15. Terence C. Burnham & Jay Phelan, 2020. "Ordinaries," Journal of Bioeconomics, Springer, vol. 22(1), pages 1-14, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:kap:jbioec:v:20:y:2018:i:1:d:10.1007_s10818-017-9262-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.