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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Author

Listed:
  • Ricki J. Colman

    (Wisconsin National Primate Research Center, University of Wisconsin)

  • T. Mark Beasley

    (Geriatrics Research, Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital
    University of Alabama)

  • Joseph W. Kemnitz

    (University of Wisconsin)

  • Sterling C. Johnson

    (Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital
    University of Wisconsin)

  • Richard Weindruch

    (Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital
    University of Wisconsin)

  • Rozalyn M. Anderson

    (Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital
    University of Wisconsin)

Abstract

Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR’s effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood. These data contrast with observations in the 2012 NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR. Our data indicate that the benefits of CR on ageing are conserved in primates.

Suggested Citation

  • Ricki J. Colman & T. Mark Beasley & Joseph W. Kemnitz & Sterling C. Johnson & Richard Weindruch & Rozalyn M. Anderson, 2014. "Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys," Nature Communications, Nature, vol. 5(1), pages 1-5, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4557
    DOI: 10.1038/ncomms4557
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    Cited by:

    1. Sebastian Brandhorst & Morgan E. Levine & Min Wei & Mahshid Shelehchi & Todd E. Morgan & Krishna S. Nayak & Tanya Dorff & Kurt Hong & Eileen M. Crimmins & Pinchas Cohen & Valter D. Longo, 2024. "Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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