IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms14063.html
   My bibliography  Save this article

Caloric restriction improves health and survival of rhesus monkeys

Author

Listed:
  • Julie A. Mattison

    (Translational Gerontology Branch, National Institute on Aging)

  • Ricki J. Colman

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • T. Mark Beasley

    (University of Alabama
    Geriatric Research Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital)

  • David B. Allison

    (University of Alabama)

  • Joseph W. Kemnitz

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • George S. Roth

    (GeroScience)

  • Donald K. Ingram

    (Pennington Biomedical Research Center)

  • Richard Weindruch

    (University of Wisconsin
    Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital)

  • Rafael de Cabo

    (Translational Gerontology Branch, National Institute on Aging)

  • Rozalyn M. Anderson

    (University of Wisconsin
    Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital)

Abstract

Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated to determine the effect of CR in rhesus monkeys. The University of Wisconsin study reported a significant positive impact of CR on survival, but the National Institute on Aging study detected no significant survival effect. Here we present a direct comparison of longitudinal data from both studies including survival, bodyweight, food intake, fasting glucose levels and age-related morbidity. We describe differences in study design that could contribute to differences in outcomes, and we report species specificity in the impact of CR in terms of optimal onset and diet. Taken together these data confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health.

Suggested Citation

  • Julie A. Mattison & Ricki J. Colman & T. Mark Beasley & David B. Allison & Joseph W. Kemnitz & George S. Roth & Donald K. Ingram & Richard Weindruch & Rafael de Cabo & Rozalyn M. Anderson, 2017. "Caloric restriction improves health and survival of rhesus monkeys," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14063
    DOI: 10.1038/ncomms14063
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms14063
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms14063?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. John P. Phelan, 2018. "Generating insights into human aging from experimental evolution using bats (or other “slow” life history species)," Journal of Bioeconomics, Springer, vol. 20(1), pages 165-173, April.
    2. Elite Possik & Laura-Lee Klein & Perla Sanjab & Ruyuan Zhu & Laurence Côté & Ying Bai & Dongwei Zhang & Howard Sun & Anfal Al-Mass & Abel Oppong & Rasheed Ahmad & Alex Parker & S.R. Murthy Madiraju & , 2023. "Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Sebastian Brandhorst & Morgan E. Levine & Min Wei & Mahshid Shelehchi & Todd E. Morgan & Krishna S. Nayak & Tanya Dorff & Kurt Hong & Eileen M. Crimmins & Pinchas Cohen & Valter D. Longo, 2024. "Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Hagai Yanai & Bongsoo Park & Hyunwook Koh & Hyo Jung Jang & Kelli L. Vaughan & Mayuri Tanaka-Yano & Miguel Aon & Madison Blanton & Ilhem Messaoudi & Alberto Diaz-Ruiz & Julie A. Mattison & Isabel Beer, 2024. "Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Laura C. D. Pomatto-Watson & Monica Bodogai & Oye Bosompra & Jonathan Kato & Sarah Wong & Melissa Carpenter & Eleonora Duregon & Dolly Chowdhury & Priya Krishna & Sandy Ng & Emeline Ragonnaud & Robert, 2021. "Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14063. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.