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Global surveillance of antimicrobial resistance in food animals using priority drugs maps

Author

Listed:
  • Cheng Zhao

    (ETH Zürich)

  • Yu Wang

    (ETH Zürich)

  • Ranya Mulchandani

    (ETH Zürich)

  • Thomas P. Van Boeckel

    (ETH Zürich
    One Health Trust
    Université Libre de Bruxelles)

Abstract

Antimicrobial resistance (AMR) in food animals is a growing threat to animal health and potentially to human health. In resource-limited settings, allocating resources to address AMR can be guided with maps. Here, we mapped AMR prevalence in 7 antimicrobials in Escherichia coli and nontyphoidal Salmonella species across low- and middle-income countries (LIMCs), using 1088 point-prevalence surveys in combination with a geospatial model. Hotspots of AMR were predicted in China, India, Brazil, Chile, and part of central Asia and southeastern Africa. The highest resistance prevalence was for tetracycline (59% for E. coli and 54% for nontyphoidal Salmonella, average across LMICs) and lowest for cefotaxime (33% and 19%). We also identified the antimicrobial with the highest probability of resistance exceeding critical levels (50%) in the future (1.7–12.4 years) for each 10 × 10 km pixel on the map. In Africa and South America, 78% locations were associated with penicillins or tetracyclines crossing 50% resistance in the future. In contrast, in Asia, 77% locations were associated with penicillins or sulphonamides. Our maps highlight diverging geographic trends of AMR prevalence across antimicrobial classes, and can be used to target AMR surveillance in AMR hotspots for priority antimicrobial classes.

Suggested Citation

  • Cheng Zhao & Yu Wang & Ranya Mulchandani & Thomas P. Van Boeckel, 2024. "Global surveillance of antimicrobial resistance in food animals using priority drugs maps," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45111-7
    DOI: 10.1038/s41467-024-45111-7
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    References listed on IDEAS

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    1. Georges P. Schmartz & Jacqueline Rehner & Miriam J. Schuff & Leidy-Alejandra G. Molano & Sören L. Becker & Marcin Krawczyk & Azat Tagirdzhanov & Alexey Gurevich & Richard Francke & Rolf Müller & Veren, 2024. "Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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