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The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

Author

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  • Natalie J. E. Waller

    (University of Otago
    University of Auckland)

  • Chen-Yi Cheung

    (University of Otago)

  • Gregory M. Cook

    (University of Otago
    University of Auckland)

  • Matthew B. McNeil

    (University of Otago
    University of Auckland)

Abstract

The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished the efficacy of almost all available antibiotics, complicating efforts to combat the spread of this global health burden. Alongside the development of new drugs, optimised drug combinations are needed to improve treatment success and prevent the further spread of antibiotic resistance. Typically, antibiotic resistance leads to reduced sensitivity, yet in some cases the evolution of drug resistance can lead to enhanced sensitivity to unrelated drugs. This phenomenon of collateral sensitivity is largely unexplored in M. tuberculosis but has the potential to identify alternative therapeutic strategies to combat drug-resistant strains that are unresponsive to current treatments. Here, by using drug susceptibility profiling, genomics and evolutionary studies we provide evidence for the existence of collateral drug sensitivities in an isogenic collection M. tuberculosis drug-resistant strains. Furthermore, in proof-of-concept studies, we demonstrate how collateral drug phenotypes can be exploited to select against and prevent the emergence of drug-resistant strains. This study highlights that the evolution of drug resistance in M. tuberculosis leads to collateral drug responses that can be exploited to design improved drug regimens.

Suggested Citation

  • Natalie J. E. Waller & Chen-Yi Cheung & Gregory M. Cook & Matthew B. McNeil, 2023. "The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37184-7
    DOI: 10.1038/s41467-023-37184-7
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    References listed on IDEAS

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    1. Linda B. S. Aulin & Apostolos Liakopoulos & Piet H. Graaf & Daniel E. Rozen & J. G. Coen van Hasselt, 2021. "Design principles of collateral sensitivity-based dosing strategies," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Nicole L. Podnecky & Elizabeth G. A. Fredheim & Julia Kloos & Vidar Sørum & Raul Primicerio & Adam P. Roberts & Daniel E. Rozen & Ørjan Samuelsen & Pål J. Johnsen, 2018. "Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    3. Daniel Nichol & Joseph Rutter & Christopher Bryant & Andrea M. Hujer & Sai Lek & Mark D. Adams & Peter Jeavons & Alexander R. A. Anderson & Robert A. Bonomo & Jacob G. Scott, 2019. "Antibiotic collateral sensitivity is contingent on the repeatability of evolution," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    4. Tiago Beites & Kathryn O’Brien & Divya Tiwari & Curtis A. Engelhart & Shaun Walters & Jenna Andrews & Hee-Jeong Yang & Michelle L. Sutphen & Danielle M. Weiner & Emmanuel K. Dayao & Matthew Zimmerman , 2019. "Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
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    Cited by:

    1. Kehan Wu & Yingce Xia & Pan Deng & Renhe Liu & Yuan Zhang & Han Guo & Yumeng Cui & Qizhi Pei & Lijun Wu & Shufang Xie & Si Chen & Xi Lu & Song Hu & Jinzhi Wu & Chi-Kin Chan & Shawn Chen & Liangliang Z, 2024. "TamGen: drug design with target-aware molecule generation through a chemical language model," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. XinYue Wang & William J. Jowsey & Chen-Yi Cheung & Caitlan J. Smart & Hannah R. Klaus & Noon EJ Seeto & Natalie JE Waller & Michael T. Chrisp & Amanda L. Peterson & Boatema Ofori-Anyinam & Emily Stron, 2024. "Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Boatema Ofori-Anyinam & Meagan Hamblin & Miranda L. Coldren & Barry Li & Gautam Mereddy & Mustafa Shaikh & Avi Shah & Courtney Grady & Navpreet Ranu & Sean Lu & Paul C. Blainey & Shuyi Ma & James J. C, 2024. "Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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