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Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

Author

Listed:
  • Han Zhang

    (Zhejiang University School of Medicine)

  • Rahul Kalla

    (University of Edinburgh)

  • Jie Chen

    (Zhejiang University School of Medicine)

  • Jianhui Zhao

    (Zhejiang University School of Medicine)

  • Xuan Zhou

    (Zhejiang University School of Medicine
    University of Edinburgh)

  • Alex Adams

    (University of Oxford, John Radcliffe Hospital)

  • Alexandra Noble

    (University of Oxford, John Radcliffe Hospital)

  • Nicholas T. Ventham

    (University of Edinburgh, Western General Hospital)

  • Judith Wellens

    (University of Oxford, John Radcliffe Hospital
    KU Leuven)

  • Gwo-Tzer Ho

    (University of Edinburgh)

  • Malcolm G. Dunlop

    (University of Edinburgh)

  • Jan Krzysztof Nowak

    (Poznan University of Medical Sciences)

  • Yuan Ding

    (Zhejiang University School of Medicine)

  • Zhanju Liu

    (Tongji University School of Medicine)

  • Jack Satsangi

    (University of Oxford, John Radcliffe Hospital)

  • Evropi Theodoratou

    (University of Edinburgh
    University of Edinburgh)

  • Xue Li

    (Zhejiang University School of Medicine
    University of Edinburgh)

Abstract

This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the risks of Crohn’s disease (CD) and ulcerative colitis (UC). We then perform both genome-wide methylation analysis and co-localization analysis to validate the observed associations. Compared to never smoking, current and previous smoking habits are associated with increased CD (P = 7.09 × 10−10) and UC (P

Suggested Citation

  • Han Zhang & Rahul Kalla & Jie Chen & Jianhui Zhao & Xuan Zhou & Alex Adams & Alexandra Noble & Nicholas T. Ventham & Judith Wellens & Gwo-Tzer Ho & Malcolm G. Dunlop & Jan Krzysztof Nowak & Yuan Ding , 2024. "Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44841-y
    DOI: 10.1038/s41467-024-44841-y
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    References listed on IDEAS

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