IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-44736-y.html
   My bibliography  Save this article

Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy

Author

Listed:
  • Mengmeng Xia

    (Anhui Normal University)

  • Qiyue Wang

    (Shanghai Jiao Tong University)

  • Yamin Liu

    (Shanghai Jiao Tong University)

  • Chunyan Fang

    (Shanghai Jiao Tong University)

  • Bo Zhang

    (Shanghai Jiao Tong University
    World Laureates Association (WLA) Laboratories)

  • Shengfei Yang

    (Zhejiang University)

  • Fu Zhou

    (Anhui Normal University)

  • Peihua Lin

    (Shanghai Jiao Tong University)

  • Mingzheng Gu

    (Anhui Normal University)

  • Canyu Huang

    (Shanghai Jiao Tong University)

  • Xiaojun Zhang

    (Anhui Normal University)

  • Fangyuan Li

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
    Shanghai Jiao Tong University School of Medicine)

  • Hongying Liu

    (Hangzhou Dianzi University)

  • Guangfeng Wang

    (Anhui Normal University)

  • Daishun Ling

    (Shanghai Jiao Tong University
    World Laureates Association (WLA) Laboratories)

Abstract

Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy.

Suggested Citation

  • Mengmeng Xia & Qiyue Wang & Yamin Liu & Chunyan Fang & Bo Zhang & Shengfei Yang & Fu Zhou & Peihua Lin & Mingzheng Gu & Canyu Huang & Xiaojun Zhang & Fangyuan Li & Hongying Liu & Guangfeng Wang & Dais, 2024. "Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44736-y
    DOI: 10.1038/s41467-024-44736-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-44736-y
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-44736-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Mei Zhu & Shengliang Wang & Zhenhui Li & Junbo Li & Zhijun Xu & Xiaoman Liu & Xin Huang, 2023. "Tyrosine residues initiated photopolymerization in living organisms," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Yong Wang & Jingming Zhang & Boyang Han & Linzhi Tan & Wenkang Cai & Yuxuan Li & Yeyu Su & Yutong Yu & Xin Wang & Xiaojiang Duan & Haoyu Wang & Xiaomeng Shi & Jing Wang & Xing Yang & Tao Liu, 2023. "Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Hyung-Seok Jang & Jung-Ho Lee & Yong-Sun Park & Young-O Kim & Jimin Park & Tae-Youl Yang & Kyoungsuk Jin & Jaehun Lee & Sunghak Park & Jae Myoung You & Ki-Woong Jeong & Areum Shin & In-Seon Oh & Min-K, 2014. "Tyrosine-mediated two-dimensional peptide assembly and its role as a bio-inspired catalytic scaffold," Nature Communications, Nature, vol. 5(1), pages 1-11, May.
    4. Meng Xu & Qiang Li & Yuzhu Song & Yuanji Xu & Andrea Sanson & Naike Shi & Na Wang & Qiang Sun & Changtian Wang & Xin Chen & Yongqiang Qiao & Feixiang Long & Hui Liu & Qiang Zhang & Alessandro Venier &, 2023. "Giant uniaxial negative thermal expansion in FeZr2 alloy over a wide temperature range," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    5. Fangyuan Li & Heng Sun & Jiafeng Ren & Bo Zhang & Xi Hu & Chunyan Fang & Jiyoung Lee & Hongzhou Gu & Daishun Ling, 2022. "A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Xiangzhao Ai & Chris Jun Hui Ho & Junxin Aw & Amalina Binte Ebrahim Attia & Jing Mu & Yu Wang & Xiaoyong Wang & Yong Wang & Xiaogang Liu & Huabing Chen & Mingyuan Gao & Xiaoyuan Chen & Edwin K.L. Yeow, 2016. "In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ziyang Cao & Dongdong Li & Liang Zhao & Mengting Liu & Pengyue Ma & Yingli Luo & Xianzhu Yang, 2022. "Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Ke Chen & Guo Li & Xiaoqun Gong & Qinjuan Ren & Junying Wang & Shuang Zhao & Ling Liu & Yuxing Yan & Qingshan Liu & Yang Cao & Yaoyao Ren & Qiong Qin & Qi Xin & Shu-Lin Liu & Peiyu Yao & Bo Zhang & Ji, 2024. "Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Peihua Lin & Bo Zhang & Hongli Yang & Shengfei Yang & Pengpeng Xue & Ying Chen & Shiyi Yu & Jichao Zhang & Yixiao Zhang & Liwei Chen & Chunhai Fan & Fangyuan Li & Daishun Ling, 2024. "An artificial protein modulator reprogramming neuronal protein functions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Xiaoying Kang & Yuan Zhang & Jianwen Song & Lu Wang & Wen Li & Ji Qi & Ben Zhong Tang, 2023. "A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Jianwen Song & Xiaoying Kang & Lu Wang & Dan Ding & Deling Kong & Wen Li & Ji Qi, 2023. "Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44736-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.