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Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy

Author

Listed:
  • Mengmeng Xia

    (Anhui Normal University)

  • Qiyue Wang

    (Shanghai Jiao Tong University)

  • Yamin Liu

    (Shanghai Jiao Tong University)

  • Chunyan Fang

    (Shanghai Jiao Tong University)

  • Bo Zhang

    (Shanghai Jiao Tong University
    World Laureates Association (WLA) Laboratories)

  • Shengfei Yang

    (Zhejiang University)

  • Fu Zhou

    (Anhui Normal University)

  • Peihua Lin

    (Shanghai Jiao Tong University)

  • Mingzheng Gu

    (Anhui Normal University)

  • Canyu Huang

    (Shanghai Jiao Tong University)

  • Xiaojun Zhang

    (Anhui Normal University)

  • Fangyuan Li

    (Zhejiang University
    Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
    Shanghai Jiao Tong University School of Medicine)

  • Hongying Liu

    (Hangzhou Dianzi University)

  • Guangfeng Wang

    (Anhui Normal University)

  • Daishun Ling

    (Shanghai Jiao Tong University
    World Laureates Association (WLA) Laboratories)

Abstract

Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy.

Suggested Citation

  • Mengmeng Xia & Qiyue Wang & Yamin Liu & Chunyan Fang & Bo Zhang & Shengfei Yang & Fu Zhou & Peihua Lin & Mingzheng Gu & Canyu Huang & Xiaojun Zhang & Fangyuan Li & Hongying Liu & Guangfeng Wang & Dais, 2024. "Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44736-y
    DOI: 10.1038/s41467-024-44736-y
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    References listed on IDEAS

    as
    1. Mei Zhu & Shengliang Wang & Zhenhui Li & Junbo Li & Zhijun Xu & Xiaoman Liu & Xin Huang, 2023. "Tyrosine residues initiated photopolymerization in living organisms," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
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