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A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis

Author

Listed:
  • Joaquín Clúa

    (University of Lausanne)

  • Jonatan Montpetit

    (University of Lausanne)

  • Pedro Jimenez-Sandoval

    (University of Lausanne)

  • Christin Naumann

    (Leibniz Institute of Plant Biochemistry)

  • Julia Santiago

    (University of Lausanne)

  • Yves Poirier

    (University of Lausanne)

Abstract

Arabidopsis primary root growth response to phosphate (Pi) deficiency is mainly controlled by changes in apoplastic iron (Fe). Upon Pi deficiency, apoplastic Fe deposition in the root apical meristem activates pathways leading to the arrest of meristem maintenance and inhibition of cell elongation. Here, we report that a member of the uncharacterized cytochrome b561 and DOMON domain (CYBDOM) protein family, named CRR, promotes iron reduction in an ascorbate-dependent manner and controls apoplastic iron deposition. Under low Pi, the crr mutant shows an enhanced reduction of primary root growth associated with increased apoplastic Fe in the root meristem and a reduction in meristematic cell division. Conversely, CRR overexpression abolishes apoplastic Fe deposition rendering primary root growth insensitive to low Pi. The crr single mutant and crr hyp1 double mutant, harboring a null allele in another member of the CYDOM family, shows increased tolerance to high-Fe stress upon germination and seedling growth. Conversely, CRR overexpression is associated with increased uptake and translocation of Fe to the shoot and results in plants highly sensitive to Fe excess. Our results identify a ferric reductase implicated in Fe homeostasis and developmental responses to abiotic stress, and reveal a biological role for CYBDOM proteins in plants.

Suggested Citation

  • Joaquín Clúa & Jonatan Montpetit & Pedro Jimenez-Sandoval & Christin Naumann & Julia Santiago & Yves Poirier, 2024. "A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-43911-x
    DOI: 10.1038/s41467-023-43911-x
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    References listed on IDEAS

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    1. Nigel J. Robinson & Catherine M. Procter & Erin L. Connolly & Mary Lou Guerinot, 1999. "A ferric-chelate reductase for iron uptake from soils," Nature, Nature, vol. 397(6721), pages 694-697, February.
    2. Coline Balzergue & Thibault Dartevelle & Christian Godon & Edith Laugier & Claudia Meisrimler & Jean-Marie Teulon & Audrey Creff & Marie Bissler & Corinne Brouchoud & Agnès Hagège & Jens Müller & Serg, 2017. "Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation," Nature Communications, Nature, vol. 8(1), pages 1-16, August.
    3. Xing Xing Liu & Hai Hua Zhang & Qing Yang Zhu & Jia Yuan Ye & Ya Xin Zhu & Xiang Ting Jing & Wen Xin Du & Miao Zhou & Xian Yong Lin & Shao Jian Zheng & Chong Wei Jin, 2022. "Phloem iron remodels root development in response to ammonium as the major nitrogen source," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Takanori Kobayashi & Seiji Nagasaka & Takeshi Senoura & Reiko Nakanishi Itai & Hiromi Nakanishi & Naoko K. Nishizawa, 2013. "Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation," Nature Communications, Nature, vol. 4(1), pages 1-12, December.
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