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Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation

Author

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  • Takanori Kobayashi

    (Japan Science and Technology Agency, PRESTO
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University)

  • Seiji Nagasaka

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo
    Present address: Faculty of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun, Gunma 374-0193, Japan)

  • Takeshi Senoura

    (Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University)

  • Reiko Nakanishi Itai

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo)

  • Hiromi Nakanishi

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo)

  • Naoko K. Nishizawa

    (Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
    Graduate School of Agricultural and Life Sciences, The University of Tokyo)

Abstract

Iron is essential for most living organisms. Plants transcriptionally induce genes involved in iron acquisition under conditions of low iron availability, but the nature of the deficiency signal and its sensors are unknown. Here we report the identification of new iron regulators in rice, designated O ryza s ativa Haemerythrin motif-containing Really Interesting New Gene (RING)- and Zinc-finger protein 1 (OsHRZ1) and OsHRZ2. OsHRZ1, OsHRZ2 and their Arabidopsis homologue BRUTUS bind iron and zinc, and possess ubiquitination activity. OsHRZ1 and OsHRZ2 are susceptible to degradation in roots irrespective of iron conditions. OsHRZ-knockdown plants exhibit substantial tolerance to iron deficiency, and accumulate more iron in their shoots and grains irrespective of soil iron conditions. The expression of iron deficiency-inducible genes involved in iron utilization is enhanced in OsHRZ-knockdown plants, mostly under iron-sufficient conditions. These results suggest that OsHRZ1 and OsHRZ2 are iron-binding sensors that negatively regulate iron acquisition under conditions of iron sufficiency.

Suggested Citation

  • Takanori Kobayashi & Seiji Nagasaka & Takeshi Senoura & Reiko Nakanishi Itai & Hiromi Nakanishi & Naoko K. Nishizawa, 2013. "Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation," Nature Communications, Nature, vol. 4(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3792
    DOI: 10.1038/ncomms3792
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    Cited by:

    1. Chen Bai & Gao-Jie Wang & Xiao-Hui Feng & Qiong Gao & Wei-Qing Wang & Ran Xu & Su-Jie Guo & Shao-Yan Shen & Ming Ma & Wen-Hui Lin & Chun-Ming Liu & Yunhai Li & Xian-Jun Song, 2024. "OsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Joaquín Clúa & Jonatan Montpetit & Pedro Jimenez-Sandoval & Christin Naumann & Julia Santiago & Yves Poirier, 2024. "A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Momoyo Ito & Yuri Tajima & Mari Ogawa-Ohnishi & Hanna Nishida & Shohei Nosaki & Momona Noda & Naoyuki Sotta & Kensuke Kawade & Takehiro Kamiya & Toru Fujiwara & Yoshikatsu Matsubayashi & Takuya Suzaki, 2024. "IMA peptides regulate root nodulation and nitrogen homeostasis by providing iron according to internal nitrogen status," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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