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A ferric-chelate reductase for iron uptake from soils

Author

Listed:
  • Nigel J. Robinson

    (The Medical School, University of Newcastle)

  • Catherine M. Procter

    (The Medical School, University of Newcastle)

  • Erin L. Connolly

    (Dartmouth College)

  • Mary Lou Guerinot

    (Dartmouth College)

Abstract

Iron deficiency afflicts more than three billion people worldwide1, and plants are the principal source of iron in most diets. Low availability of iron often limits plant growth because iron forms insoluble ferric oxides, leaving only a small, organically complexed fraction in soil solutions2. The enzyme ferric-chelate reductase is required for most plants to acquire soluble iron. Here we report the isolation of the FRO2 gene, which is expressed in iron-deficient roots of Arabidopsis. FRO2 belongs to a superfamily of flavocytochromes that transport electrons across membranes. It possesses intramembranous binding sites for haem and cytoplasmic binding sites for nucleotide cofactors that donate and transfer electrons. We show that FRO2 is allelic to the frd1 mutations that impair the activity of ferric-chelate reductase3. There is a nonsense mutation within the first exon of FRO2 in frd1-1 and a missense mutation within FRO2 in frd1-3. Introduction of functional FRO2 complements the frd1-1 phenotype in transgenic plants. The isolation of FRO2 has implications for the generation of crops with improved nutritional quality and increased growth in iron-deficient soils.

Suggested Citation

  • Nigel J. Robinson & Catherine M. Procter & Erin L. Connolly & Mary Lou Guerinot, 1999. "A ferric-chelate reductase for iron uptake from soils," Nature, Nature, vol. 397(6721), pages 694-697, February.
  • Handle: RePEc:nat:nature:v:397:y:1999:i:6721:d:10.1038_17800
    DOI: 10.1038/17800
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    Cited by:

    1. Joaquín Clúa & Jonatan Montpetit & Pedro Jimenez-Sandoval & Christin Naumann & Julia Santiago & Yves Poirier, 2024. "A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. A. Gholizadeh & B. Baghban Kohnehrouz & H. Hekmatshoar, 2007. "Step-by-step morpho-physiological responses of Arachis hypogaea L. cv. NC 2 to iron deficiency," Plant, Soil and Environment, Czech Academy of Agricultural Sciences, vol. 53(7), pages 290-298.
    3. Rodolfo A. Maniero & Cristiana Picco & Anja Hartmann & Felipe Engelberger & Antonella Gradogna & Joachim Scholz-Starke & Michael Melzer & Georg Künze & Armando Carpaneto & Nicolaus Wirén & Ricardo F. , 2024. "Ferric reduction by a CYBDOM protein counteracts increased iron availability in root meristems induced by phosphorus deficiency," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Qiang Liu & Tsubasa Kawai & Yoshiaki Inukai & Dan Aoki & Zhihang Feng & Yihui Xiao & Kazuhiko Fukushima & Xianyong Lin & Weiming Shi & Wolfgang Busch & Yasuyuki Matsushita & Baohai Li, 2023. "A lignin-derived material improves plant nutrient bioavailability and growth through its metal chelating capacity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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